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Enlaza Therapeutics Collaborates with Vertex to Develop Drug Conjugates and T-Cell Engagers for Improved Conditioning and Autoimmune Diseases

Shots:

  • Enlaza & Vertex’s muti-target collaboration will leverage Enlaza’s War-Lock platform to develop small format drug conjugates & T-cell engagers for autoimmune diseases & improved conditioning in sickle cell disease & β thalassemia
  • Enlaza will receive $45M in upfront & equity investment & is eligible for >$2B in research, development, regulatory, & commercial milestones plus tiered royalties; it will lead research to candidate nomination, with Vertex funding the 4yr. collaboration & assuming all subsequent R&D, manufacturing, & commercialization
  • War-Lock platform uses proprietary non-natural amino acids to create covalent proteins with small-format biologic selectivity to expand the therapeutic window across modalities

Ref: Enlaza| Image: Enlaza & Vertex | Press Release

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