Shots:
Ultragenyx has entered into a definitive agreement to sell a Rare Pediatric Disease PRV for $210M, provide Ultragenyx with significant non-dilutive capital to advance therapies for rare & ultra-rare diseases
Rare Pediatric Disease PRV was received following FDA approval of Genglycos (pariglasgene brecaparvovec-opnr), the first treatment targeting the underlying cause of glycogen storage disease…
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Orion Pharma & Qilu Pharma EU have entered into an agreement to commercialise IV pembrolizumab biosimilar in Europe, which is currently developed by Qilu
As per the deal, Orion will gain exclusive right to distribute, market & sell Qilu’s IV pembrolizumab biosimilar in the EU, while Qilu will supply the product & receive a…
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CSL & Alentis Therapeutics have entered into an exclusive global collaboration agreement to co-develop & co-promote lixudebart across a range of kidney, liver and other diseases
CSL & Alentis will jointly develop & co-promote lixudebart, with CSL paying $355M upfront & Alentis receiving up to $1.2B in commercial milestones. Once commercialised, global profits will…
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Italfarmaco & JCR Pharmaceuticals have entered an exclusive license agreement to develop & potentially commercialize JR-141 (pabinafusp alfa) in the US, Europe, & Latin America for Hunter syndrome (MPS II)
The companies seek approvals for JR-141 in the US, EU, UK & Brazil. Following approval, Italfarmaco will commercialize & distribute JR-141 in licensed territories,…
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Abogen has entered into a licensing & option agreement, granting Novartis an exclusive worldwide license to ABO2203, as well as options to exclusively license other potential programs that leverage Abogen's RNA platform
As per the deal, Abogen will receive ~$575M upfront &, if all options on all programs are exercised, Abogen will gain ~$7.2B…
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The companies expanded their alliance to add 4 long-acting, Regeneron-invented antibodies targeting IL-13 (REGN20423), IL-4×IL-13 bispecific, IL-4 & IL-4Rα. REGN20423 is in P-I for atopic dermatitis, while the other 3 are expected to enter clinical studies in 2027
As per the expanded agreement, Regeneron & Sanofi will co-develop & co-commercialize the assets, with Regeneron…
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Tolerance Bio has entered into an exclusive license agreement with Tanabe Pharma for MT-2990, an anti-IL-33 monoclonal antibody, across all indications
Tanabe Pharma has granted Tolerance Bio worldwide development & manufacturing rights, and ex-Japan exclusive commercialization rights for MT-2990 (TLB-33), while Tanabe will retain commercialization rights in Japan
As per the deal, Tanabe will…
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AstraZeneca will invest $2B in Summit through convertible preferred shares, representing a conversion price of $18.36/share, while the companies will collaborate on the development of ivonescimab & sonesitatug vedotin (sone-ve).
The clinical collaboration will evaluate ivonescimab with sone-ve in GI cancers, with studies expected to begin soon. Companies will share study costs, while each…
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Hengrui Pharma has entered into a license agreement with Novo for HRS-1596, a P-I-ready GLP-1 receptor & gastric inhibitory polypeptide receptor dual agonist, with potential for QW oral dosing
As per the deal, Novo will obtain exclusive rights to develop, manufacture & commercialize HRS-1596 globally, excl. Mainland China, the Hong Kong SAR, the Macao…
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Nanexa has entered into a global exclusive license & collaboration agreement with Novo for the use of its PharmaShell ALD drug delivery technology platform, for certain peptide-based drugs targeting obesity, T2D & other cardiometabolic indications
As per the deal, Novo will receive a global license to Nanexa’s PharmaShell platform for use in ~5 development programs,…

