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Ultragenyx to Sell Rare Pediatric Disease Voucher for $210M

Shots: Ultragenyx has entered into a definitive agreement to sell a Rare Pediatric Disease PRV for $210M, provide Ultragenyx with significant non-dilutive capital to advance therapies for rare & ultra-rare diseases Rare Pediatric Disease PRV was received following FDA approval of Genglycos (pariglasgene brecaparvovec-opnr), the first treatment targeting the underlying cause of glycogen storage disease…

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CSL and Alentis Therapeutics Ink ~$1.55B Global Collaboration to Advance Lixudebart

Shots: CSL & Alentis Therapeutics have entered into an exclusive global collaboration agreement to co-develop & co-promote lixudebart across a range of kidney, liver and other diseases CSL & Alentis will jointly develop & co-promote lixudebart, with CSL paying $355M upfront & Alentis receiving up to $1.2B in commercial milestones. Once commercialised, global profits will…

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Abogen and Novartis Partner to Advance RNA-Encoded Therapeutics in $575M Upfront, $7.2B Milestone Deal

Shots: Abogen has entered into a licensing & option agreement, granting Novartis an exclusive worldwide license to ABO2203, as well as options to exclusively license other potential programs that leverage Abogen's RNA platform As per the deal, Abogen will receive ~$575M upfront &, if all options on all programs are exercised, Abogen will gain ~$7.2B…

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Regeneron & Sanofi

Regeneron and Sanofi Expand Immunology Alliance in a Deal Valued at ~$8B

Shots: The companies expanded their alliance to add 4 long-acting, Regeneron-invented antibodies targeting IL-13 (REGN20423), IL-4×IL-13 bispecific, IL-4 & IL-4Rα. REGN20423 is in P-I for atopic dermatitis, while the other 3 are expected to enter clinical studies in 2027 As per the expanded agreement, Regeneron & Sanofi will co-develop & co-commercialize the assets, with Regeneron…

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Tolerance Bio and Tanabe Pharma Partner for MT-2990 in Deal With Up to $560M in Milestones

Shots: Tolerance Bio has entered into an exclusive license agreement with Tanabe Pharma for MT-2990, an anti-IL-33 monoclonal antibody, across all indications Tanabe Pharma has granted Tolerance Bio worldwide development & manufacturing rights, and ex-Japan exclusive commercialization rights for MT-2990 (TLB-33), while Tanabe will retain commercialization rights in Japan As per the deal, Tanabe will…

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Summit Therapeutics and AstraZeneca Enter $2B Strategic Investment and Oncology Collaboration

Shots: AstraZeneca will invest $2B in Summit through convertible preferred shares, representing a conversion price of $18.36/share, while the companies will collaborate on the development of ivonescimab & sonesitatug vedotin (sone-ve). The clinical collaboration will evaluate ivonescimab with sone-ve in GI cancers, with studies expected to begin soon. Companies will share study costs, while each…

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