Shots:
- The integration of innovative technologies in healthcare, such as digital health platforms and AI-enabled applications, is transforming the way diseases are detected, diagnosed, treated, and prevented
- The global Digital Health market is expected to reach $197.88B in 2025 and grow at a CAGR of 6.88%, reaching $258.25B by 2029
- PharmaShots presents a concise report on the 20 Innovative Digital Therapeutic Companies of 2025, offering insights into the key players driving this evolving space
20. CureApp
Founded Year: 2014
Headquarters: Tokyo, Japan
- CureApp is a Japanese digital therapeutics company developing FDA/PMDA-approved prescription apps for chronic lifestyle-related conditions such as hypertension, smoking cessation, NASH, alcohol addiction, heart failure, and low back pain
- Its key offerings include CureApp HT (for hypertension), CureApp SC (nicotine addiction support with CO checker), and a pipeline targeting NASH, alcohol use disorder, oncology, heart failure, and chronic back pain
- In June 2024, CureApp signed a joint marketing and sales agreement with Teijin Pharma in Japan to expand distribution of CureApp HT
19. Headspace Health
Founded Year: 2010
Headquarters: California, United States
- Headspace Health is a digital mental health platform offering 24/7 on-demand behavioral health coaching, therapy, psychiatry, and self-guided support via its mobile app
- The platform integrates AI-assisted text coaching, video-based therapy, psychiatry sessions, and tools for mindfulness, mood tracking, and care navigation into a single ecosystem
- In February 2025, Headspace merged with Ginger, forming a combined $3B digital mental health company
18. Cognoa
Founded Year: 2013
Headquarters: California, United States
- Cognoa is a pediatric digital therapeutics company offering AI-driven diagnostic and treatment tools for early childhood behavioral and developmental conditions including autism, ADHD, and anxiety
- Its flagship product, Canvas Dx, is the first FDA-authorized digital diagnostic tool for autism in children aged 18–72 months. The company is expanding into therapeutics for speech development, ADHD, and anxiety
- In September 2024, Wyoming Medicaid became the first state program to cover Canvas Dx, increasing access to early autism diagnosis
17. Cognifit
Founded Year: 1999
Headquarters: California, United States
- Cognifit provides digital cognitive assessments and personalized brain training tools targeting memory, attention, and executive function
- It offers evidence-based games, assessments, and a developer API/SDK enabling integration across health, education, gaming, and wellness sectors
- In July 2024, Cognifit received the “Best Specialist Brain Training Software Company” award for its work in cognitive enhancement.
16. SilverCloud Health (Amwell)
Founded Year: 2012
Headquarters: Boston, United States
- SilverCloud Health delivers self-guided, CBT-based digital mental health programs addressing depression, anxiety, sleep issues, stress, and perinatal mental health
- Its library includes modules for conditions such as GAD, OCD, chronic pain, diabetes, and substance use, with features like mood tracking, journaling, and mindfulness exercises, optionally supported by human coaches
- In January 2024, SilverCloud won multiple international health-tech awards, including “Health-Tech Innovation of the Year.”
15. Well Doc
Founded Year: 2005
Headquarters: Columbia, United States
- WellDoc focuses on AI-powered digital therapeutics for cardiometabolic conditions such as diabetes, hypertension, heart failure, weight management, and GLP‑1 support
- Its flagship product, BlueStar, is a US FDA-cleared and CE-marked Class IIa therapeutic that integrates CGM, real-time sensors, and AI analytics
- In March 2024, BlueStar obtained CE mark certification under the EU MDR
14. Akili Interactive
Founded Year: 2011
Headquarters: Boston, United States
- Akili Interactive develops FDA-cleared, game-based digital therapeutics to improve cognitive function in ADHD, depression, and autism
- Key products include EndeavorRx (for pediatric ADHD) and EndeavorOTC (for adult ADHD). Additional pipeline programs address depression and cognitive impairment
- In June 2024, the FDA cleared EndeavorOTC as an over-the-counter therapeutic for adult ADHD
13. 2Morrow
Founded Year: 2011
Headquarters: Kirkland, United States
- 2Morrow provides mobile behavioral-change programs rooted in Acceptance and Commitment Therapy (ACT) targeting smoking/vaping cessation, sleep, stress, chronic pain, and weight management
- Its key offerings include 2Morrow Health and Salty for Chronic Pain
- In October 2024, the company was named “Best Behavioral Health Software Company (West Coast USA)” by Global Excellence Awards
12. Mahalo Health
Founded Year: 2020
Headquarters:
- Mahalo Health is a platform for rapid app development and decentralized trials, offering modules for remote monitoring, microlearning, medication tracking, and connected devices
- It supports digital therapeutics deployment and hybrid/digital clinical trials across diabetes, mental health, MSK, rare diseases, oncology, and NASH
- In December 2024, Mahalo launched version 1.0.15 of Mahalo Connect, enhancing secure surveys and device support.
11. daVinci Digital Therapeutics
Founded Year: 2020
Headquarters: Boston, United States
- daVinci DTx is an Italian digital therapeutics company developing prescription-grade software for chronic conditions like hypertension and insomnia, CE‑marked as medical device software
- Its approach combines medicine and software innovation by leveraging AI, digital medicine, and digital therapeutics for various indications
- In July 2024, it participated in the “Medical Research: A Journey Through Projects for the Health of the Future” conference to highlight its work in the digital health ecosystem
10. Neuroglee Health
Founded Year: 2020
Headquarters: Boston, United States
- Neuroglee Health is a digital therapeutics company delivering virtual, physician-led cognitive care for mild cognitive impairment and dementia through its Neuroglee Connect platform
- Neuroglee Health operates in memory & dementia care, partnering with primary care, neurology groups, and health plans to provide personalized cognitive exercises, remote monitoring, and caregiver support
- In July 2024, Neuroglee Health was awarded the digital health hub foundation award for mental & behavioral health
9. AppliedVR
Founded Year: 2015
Headquarters: California, United States
- AppliedVR is a pioneer in immersive therapeutics, delivering VR-based prescription treatments for chronic pain conditions
- Its FDA-authorized product, RelieVRx, is indicated for chronic low back pain and combines virtual reality headsets with CBT-based protocols
- In May 2024, AppliedVR launched RelieVRx for workers’ compensation markets, offering a non-pharmacological therapy for injured workers
8. DarioHealth
Founded Year: 2011
Headquarters: New York, United States
- DarioHealth is a digital health platform offering AI-supported programs for cardiometabolic care, MSK pain, behavioral health, and GLP‑1 support, integrated with devices and coaching
- The platform addresses diabetes, hypertension, MSK pain, and behavioral conditions through real-time analytics and connected care
- In February 2024, DarioHealth acquired Twill, expanding its platform to include behavioral health and care navigation
7. Biofourmis
Founded Year: 2015
Headquarters: Massachusetts, United States
- Biofourmis delivers AI-powered remote monitoring and digital therapeutics across cardiology, oncology, pain, and immunology
- It supports hospital-at-home programs, decentralized trials, and digital biomarkers through its Biovitals platform and device-agnostic infrastructure
- In February 2024, Biofourmis signed four agreements with top-20 pharma companies, expanding its oncology and DCT capabilities
6. SWORD Health
Founded Year: 2015
Headquarters: New York, United States
- SWORD Health is a digital therapeutics (AI Care) company delivering app-based physical therapy for musculoskeletal conditions using wearable sensors, licensed clinicians, and AI assistance
- Its product suite includes Thrive (MSK), Bloom (pelvic), Predict (surgical risk), and Phoenix (AI Care Specialist)
- In June 2024, SWORD raised $130M, boosting its valuation to $3B, and introduced its conversational AI Care Specialist, Phoenix
5. Kaia Health
Founded Year: 2016
Headquarters: New York, United States
- Kaia Health offers AI-enabled motion tracking for app-based MSK and respiratory therapy
- Its products include Kaia MSK for pain, Kaia Breathe for COPD, and Kaia Balance for fall prevention in older adults
- In May 2024, it launched its Balance Program for fall prevention, improving mobility and confidence in adults aged 65+
4. Big Health
Founded Year: 2010
Headquarters: San Francisco, United States
- Big Health delivers app-based cognitive behavioral therapy (CBT) for insomnia, anxiety, and depression through FDA-cleared programs like SleepioRx and DaylightRx
- Its solutions are used as alternatives to medication and support large-scale behavioral health deployments
- In August 2024, its insomnia app SleepioRx became an FDA-cleared prescription digital therapeutic for adults
3. Noom
Founded Year: 2008
Headquarters: New York, United States
- Noom is a digital behavior-change platform that uses app-based coaching and Cognitive Behavioral Therapy (CBT) techniques for weight loss, mental health, and chronic condition management
- Noom provides services like Noom Med, Noom Mood, and Noom Move, catering to over 45M users through personalized guidance, food logging, and community support
- In October 2024, Noom launched two enterprise-focused GLP‑1 solutions Noom Med with SmartRx and Noom Weight with GLP‑1Rx, enabling employers and health plans to offer accessible GLP‑1 medications with managed costs and projected ROI of ~4.1
2. Click Therapeutics
Founded Year: 2012
Headquarters: New York, United States
- Click Therapeutics is a digital therapeutics company that creates app-based treatments for conditions like migraine, depression, schizophrenia, and smoking cessation
- The company’s Click SE platform powers products like CT-132, a prescription digital therapeutic shown to reduce migraine days in clinical trials
- In March 2025, Click raised $145M in a Series C round, backed by Medidata and Dassault Systèmes, to scale its clinical pipeline and commercial rollout
1. Omada Health
Founded Year: 2011
Headquarters: San Francisco, United States
- Omada Health is a digital chronic-care company delivering virtual programs and smart devices to help manage diabetes, hypertension, musculoskeletal disorders, and nutrition domains
- It operates across four segments: cardiometabolic, musculoskeletal, behavioral, and nutritional segments, and is powered by human coaches and AI tools like OmadaSpark
- In June 2025, Omada went public on Nasdaq under the ticker OMDA, raising $150M at a $1.28B valuation
Sources:
- Annual reports
- SEC Filings
- Press releases
- Company websites
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