Tags : Melanoma

Regeneron Collaborates with BioNTech to Advance the Combination of FixVac

Shots: The two companies collaborated to jointly conduct P-II study combining BNT111 FixVac and Libtayo in patients with anti-PD1-refractory/relapsed, unresectable Stage III or IV cutaneous melanoma with the expected initiation of the study in Q4’20 The companies will equally share the development costs for the clinical trial and will contribute their products for the trial. […]Read More

Roche’s Tecentriq + Cotellic and Zelboraf Receives the US FDA’s

Shots: The approval is based on P-III IMspire150 study assessing Tecentriq (atezolizumab) + Cotellic  (cobimetinib) + Zelboraf (vemurafenib) vs  PBO + Cotellic +   Zelboraf in patients with BRAF V600 mutation-positive advanced melanoma Results: mPFS (15.1 vs 10.6mos.); the safety profile of the Tecentriq combination was consistent with the known safety profiles of the individual medicines. […]Read More

Merck’s Keytruda (pembrolizumab) Receives FDA’s Approval for Adjuvant Treatment of

Shots: The approval is based on P-III EORTC1325/KEYNOTE-054 trial results assessing Keytruda (pembrolizumab,200mg, q3w) vs PBO in 1019 patients in the ratio (1:1) with completely resected stage IIIA, IIIB or IIIC melanoma for 1yr or until disease recurrence or unacceptable toxicity P-III EORTC1325/KEYNOTE-054 trial results: 43% reduction in the risk of disease recurrence or death; […]Read More