Shots:
AstraZeneca has entered a worldwide exclusive research collaboration & licensing agreement with insitro to discover novel targets and advance therapeutics for metabolic dysfunction-associated steatohepatitis (MASH) and cardiomyopathies using AI
As per the deal, insitro will receive $40M upfront and is eligible for up to ~$1.46B in discovery, development & commercial milestones, plus single-digit royalties…
Shots:
Ocugen has licensed exclusive MENA rights for OCU400, its modifier gene therapy for retinitis pigmentosa, to Roots Pharmaceutical & its strategic partner Al-Dhow International Holding
As per the deal, Ocugen will receive ~$4M in upfront fee & development milestones, plus ~$255M in sales milestones, & royalties equaling 22% of OCU400 net sales by Roots…
Shots:
Vir has entered into a collaboration & license agreement with Gilead to discover & engineer 3 novel PRO-XTENdual-masked T-cell engager (TCE) development candidates targeting selected solid tumor-associated antigens
As per the deal, Vir will discover, design, & optimize three PRO-XTEN dual-masked TCE candidates, while Gilead will hold exclusive rights to nominate & advance them,…
Shots:
Rona Therapeutics has granted Roche an exclusive worldwide license to Rona’s RNAi candidate targeting activin receptor-like kinase 7 (ALK7) utilizing the company's extrahepatic delivery platform
As per the deal, Rona will receive ~$100M in upfront & near-term milestone payments, plus ~$1.06B in development, regulatory & commercial milestone payments, as well as tiered royalties on…
Shots:
Italfarmaco & JCR Pharmaceuticals have entered an exclusive license agreement to develop & potentially commercialize JR-141 (pabinafusp alfa) in the US, Europe, & Latin America for Hunter syndrome (MPS II)
The companies seek approvals for JR-141 in the US, EU, UK & Brazil. Following approval, Italfarmaco will commercialize & distribute JR-141 in licensed territories,…
Shots:
Abogen has entered into a licensing & option agreement, granting Novartis an exclusive worldwide license to ABO2203, as well as options to exclusively license other potential programs that leverage Abogen's RNA platform
As per the deal, Abogen will receive ~$575M upfront &, if all options on all programs are exercised, Abogen will gain ~$7.2B…
Shots:
Tolerance Bio has entered into an exclusive license agreement with Tanabe Pharma for MT-2990, an anti-IL-33 monoclonal antibody, across all indications
Tanabe Pharma has granted Tolerance Bio worldwide development & manufacturing rights, and ex-Japan exclusive commercialization rights for MT-2990 (TLB-33), while Tanabe will retain commercialization rights in Japan
As per the deal, Tanabe will…
Shots:
Hengrui Pharma has entered into a license agreement with Novo for HRS-1596, a P-I-ready GLP-1 receptor & gastric inhibitory polypeptide receptor dual agonist, with potential for QW oral dosing
As per the deal, Novo will obtain exclusive rights to develop, manufacture & commercialize HRS-1596 globally, excl. Mainland China, the Hong Kong SAR, the Macao…
Shots:
Nanexa has entered into a global exclusive license & collaboration agreement with Novo for the use of its PharmaShell ALD drug delivery technology platform, for certain peptide-based drugs targeting obesity, T2D & other cardiometabolic indications
As per the deal, Novo will receive a global license to Nanexa’s PharmaShell platform for use in ~5 development programs,…
Shots:
Amberstone Biosciences has entered into a collaboration & license agreement with Henlius Biotech to advance conditionally activated T-cell engagers for the treatment of solid tumors
As per the deal, Amberstone will use its T-MATE platform to generate preclinical candidates against ~2 Henlius-selected targets, while Henlius will lead subsequent research, development, manufacturing & global commercialization…

