Tags : Ionis


Akcea and Ionis Report Results of AKCEA-ANGPTL3-LRx in P-II Study

Shots: The P-II study involves assessing AKCEA-ANGPTL3-LRx (SC, 40-80mg) vs PBO in 105 patients with hypertriglyceridemia, T2D, and NAFLD for 6mos. The P-II study resulted in meeting its primary & multiple secondary endpoints with a reduction in fasting triglycerides, ANGPTL3, apoC-III, VLDL-C, non-HDL cholesterol, no reduction in liver fat and is well tolerated AKCEA-ANGPTL3-LRx is […]Read More


GSK Exercises Its Option to License Ionis’ Antisense Therapy for

Shots: Ionis to receive ~$262M milestones including $25M license fee with royalties on sales of products. GSK to exercise its option to license program following positive P-II results and will be responsible for all development, regulatory, commercialization activities and its costs  In Mar’2010, GSK and Ionis collaborated on RNA therapies for rare and infectious diseases […]Read More


ProQR Signs Exclusive Worldwide License Agreement with Ionis for IONIS-RHO-2.5

Shots: Ionis Pharmaceuticals will receive an upfront payment in ordinary shares $2.5M, $22.23/share representing 20% premium plus milestones payments and 20% royalties on net sales of QR-1123. ProQR to get WW license rights for Ionis’ IONIS-RHO-2.5 Candidate In 2019, ProQR plans onset of P-I/II trial for QR-1123 in autosomal dominant retinitis pigmentosa (adRP) with awaited […]Read More