Novo Nordisk Reports Positive P-III (HIBISCUS) Study Data for Etavopivat in Sickle Cell Disease
Shots:
- Novo Nordisk reported that etavopivat met both co-1EPs in the P-III (HIBISCUS) study, reducing vaso-occlusive crises (VOCs) and improving haemoglobin response in sickle cell disease
- The study (n=385, ≥12yrs) evaluated Etavopivat (400mg) vs PBO demonstarting reduced VOCs rates by 27% and delayed time to first VOC (~38.4 vs 20.9 weeks), while 48.7% of patients achieved >1 g/dL haemoglobin increase vs 7.2% with PBO
- Novo Nordisk plans regulatory submission in H2 2026, positioning etavopivat as a potential first-in-class oral therapy for SCD
Ref: Novo Nordisk | Image: Novo Nordisk | Press Release
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