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VectorY Therapeutics Collaborates with Shape Therapeutics to Develop Vectorized Antibodies for Neurodegenerative Diseases

Shots:

  • VectorY has entered into an option & license deal with Shape to assess Shape’s SHP-DB1 (AAV capsid) for vectorized Abs payloads against 3 targets & may secure an exclusive license for their delivery if evaluation succeeds
  • As per the deal, VectorY will handle development & commercialization of resulting therapies in exchange for an upfront payment, plus ~$1.2B in fees & milestones, incl. ~$338M for rare disease & $503.5M for non-rare disease programs, along with tiered royalties on future sales
  • Collaboration will enable IV delivery across VectorY’s pipeline, incl. VTx-003 for Huntington’s disease (IND & CTA submissions planned for 2025, with trial starting in early 2026) & VTx-005 for Alzheimer’s Disease

Ref: VectorY Therapeutics | Image: VectorY Therapeutics and Shape Therapeutics | Press Release

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