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Top Innovative Digital Therapeutics Companies of 2021

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Top Innovative Digital Therapeutics Companies of 2021

Top Innovative Digital Therapeutics Companies of 2021

​​​​​Shots:

  • The past few years have shown an accelerated development in the digital therapeutics market through various applications, tracking devices, and telemedicine being integrated into digital therapies
  • Digital therapeutics provided powerful tools to maintain the public healthcare system during the Covid-19 pandemic for the people to access treatments for both physical & psychological conditions at home
  • PharmaShots has compiled 20 innovative digital therapeutics companies of 2021 (alphabetical orders)

Founded Year: 2011

Headquarters: Washington, US

Total Employees: ~25

Therapy Areas:  Neurology

2Morrow is a digital health company bringing evidence-based behavioural change programs via smartphone apps. The company integrates technology and behavioural science to address vital healthcare issues including smoking, vaping, weight, stress/anxiety, and chronic pain. Programs are delivered via an easy-to-use smartphone application for participants and a real-time dashboard for program administrators offering both engagement data and population insights. In Apr 2021, 2Morrow raised $1.5M to develop a digital coaching software to help people to gain better healthcare results

Founded Year: 2011

Headquarters: Massachusetts, US

Total Employees: ~137

Therapy Areas: Neurology

Akili interactive is a prescription digital medicine company that builds clinically-validated cognitive therapeutics, assessments, and diagnostics with exceptional creativity and video game development. They aim to develop new technologies and programs to treat cognitive deficiency and improve symptoms associated with medical conditions across neurology and psychiatry, including attention-deficit hyperactivity/ disorder (ADHD), major depressive disorder (MDD), autism spectrum disorder (ASD), and various inflammatory diseases. In Apr 2021, Akili collaborated with the Weill Cornell Medicine, Newyork-Presbyterian Hospital, and Vanderbilt University Medical Center to assess Akili's digital therapeutic, AKL-T01 to treat patients with “COVID brain fog”, a cognitive dysfunction following COVID-19 to improve attention function.

Founded Year: 2015

Headquarters:  California, US

Total Employees: ~44

Therapy Areas: Cardiovascular, Metabolic

Better Therapeutics is a prescription digital therapeutics (PDT) company that delivers nutritional cognitive-behavioural therapies (nCBTs) to address the root causes of cardiometabolic diseases through prescribed mobile applications. The company has developed a proprietary platform for the development of FDA-regulated, software-based solutions for type2 diabetes, heart disease, and other conditions. In Apr 2021, Better therapeutics reverse-merged with Mountain Crest Acquisition Corp. II, for an equity value of $113M to advance its robust pipeline of products to treat cardiometabolic diseases. The merger was completed in Oct 2021.

Founded Year: 2015

Headquarters: Massachusetts, US

Total Employees: ~466

Therapy Areas: Neurology, Cardiology, Respiratory, Oncology

Biofourmis is a digital health company that augments personalized care and therapies using digital therapeutics. The company's platform uses its AI-powered health analytics platform to integrate & analyze continuous physiology data from clinical-grade wearables to detect personalized patterns and predict clinical exacerbation in advance of a critical event for providing better outcomes for patients. In Jul 2021, Biofourmis received Breakthrough Device designation from the US FDA for its heart failure digital medicine, BiovitalsHF solution that augments guideline-directed use of heart failure medications

Founded Year: 2011

Headquarters: Massachusetts, US

Total Employees: ~463

Therapy Areas: Multiple

Butterfly Network is a digital health company that delivers high-quality, affordable, easy-to-use, intelligently connected medical imaging techniques through its ultrasound technology made with artificial intelligence for better clinical outcomes. Butterfly iQ+ is the only ultrasound transducer that can perform whole-body imaging in a single handheld probe using semiconductor technology. In Feb 2021, Butterfly Network reverse-merged with Longview Acquisition Corp for an enterprise value of $1.5B.

Founded Year: 2012

Headquarters: New York, US

Total Employees: ~127

Therapy Areas: Neurology

Click Therapeutics develops and commercializes software as medical treatments for people with unmet medical needs. Through cognitive and neurobehavioral mechanisms, Click's Digital Therapeutics enable change within individuals and are designed to be used independently or in conjunction with biomedical treatments. In Mar 2021, Click Therapeutics partnered with youturn to provide its digital smoking cessation program, to youturn. The partnership provided better tools and resources for the treatment of behavioural and physical health problems like smoking.

Founded Year: 2013

Headquarters: California, US

Total Employees: ~70

Therapy Areas: Neurology

Cognoa is a paediatric behavioural health company developing digital diagnostics and therapeutics to enable the earlier diagnosis and treatment of behavioural health conditions like autism. The company's AI technology platform will enable Cognoa's product pipeline to address additional unmet needs including ADHD and anxiety. In Jun 2021, Cognoa received FDA Marketing Authorization for its autism diagnosis aid. The AI-based device is designed to help physicians to diagnose autism in the primary care setting.

Founded Year: 2014

Headquarters: Tokyo, Japan

Total Employees: ~51

Therapy Areas: Lifestyle Diseases, Neurology

CureApp is a digital health therapeutic medical device (software) company that provides a digital platform for consumers to manage addiction and health vitals. The company’s first product is CureApp Smoking Cessation which provides patient-specific guidance to users depending on both their status in smoking cessation (nicotine addiction), treatments, and daily physical conditions that effectively help them to mitigate the psychological aspects of nicotine addiction. In Mar 2021, CureApp completed its P-III multicenter randomized controlled trial in collaboration with Jichi Medical University for its digital therapeutics (DTx) app to treat hypertension.

Founded Year: 2011

Headquarters: New York, US

Total Employees: ~60

Therapy Areas: Metabolic, Musculoskeletal, Neurology

DarioHealth is a digital therapeutics (DTx) company that delivers personalized and dynamic interventions driven by data analytics to manage diabetes, hypertension, weight management musculoskeletal pain, and behavioural conditions. In Jan 2021, Dario Health acquired Upright Technologies to expand solutions into the MSK market that will boost its digital therapeutics platform. In Oct 2021, Dario Health collaborated with Virgin Pulse to expand the visibility of its digital therapeutics and health solutions making them available to employers and health plans globally 

Founded Year: 2010

Headquarters: Queensland, Australia

Total Employees: ~212

Therapy Areas: Infectious 

Ellume is a health technology company that develops, manufactures, and commercializes digital diagnostic products for healthcare professionals and consumers by combining next-generation quantum dot diagnostics with connected care technologies for the treatment of infectious diseases. In Feb 2021, Ellume signed a $231.8 million contract with the departments of Defense, Health and Human Services of the US government to supply the first OTC, at-home Covid-19 test kits. The kits will ease up the testing process through its mid-turbinate nasal swab which is less invasive than the original deep nasal swabs used before.

Founded Year: 2010

Headquarters: California, US

Total Employees: ~200

Therapy Areas: Metabolic, Endocrine

Glooko is the global diabetes platform that provides insights to improve outcomes for people with diabetes (PWDs) and their care teams. The company’s software platforms empower the management of diabetes and related conditions by collecting and unlocking the power of data from blood-glucose meters, CGMs, insulin pumps, connected insulin pens, blood pressure cuffs, nutrition apps, and connected scales, and activity trackers. In May 2021, Glooko collaborated with Eli Lilly and Company to expand its device-agnostic model for remote patient monitoring and patient data management through the integration of Lilly’s Tempo Pen and Tempo Smart Button with Glooko’s platform

Founded Year: 2016

Headquarters: New York, US

Total Employees: ~200

Therapy Areas:  Musculoskeletal, Pulmonary

Kaia Health is a digital therapeutics company that creates evidence-based treatments for a range of medical disorders. The company offers digital programs to help people with chronic musculoskeletal pain, including back, hip, knee, and COPD. The company uses AI, and computer vision and works with medical experts to create an interdisciplinary digital approach. In Nov 2021, Kaia Health collaborated with Luna Health for its In-Home physical therapy to extend access to its Musculoskeletal (MSK) care thus making the effective therapies accessible to patients anywhere and at any time.

Founded Year: 2011

Headquarters: California, US

Total Employees: ~200

Therapy Areas: Chronic Diseases

Lark Health develops an AI-based chronic disease management platform for diabetes, hypertension, and behavioural health. It is a digital health start-up that provides virtual care through AI coaching, smart devices, and telemonitoring. In Feb 2021, Lark Health partnered with Medical Mutual. The integration of Lark’s A.I.-based chronic disease prevention and management programs and Medical Mutual’s population health model created personalized support customized to a member’s health and engagement preferences, ultimately leveraging Lark’s digital platform

Founded Year: 2008

Headquarters: New York, US

Total Employees: ~5,000

Therapy Areas: Metabolic, Endocrine, Neurology

Noom is a psychology-based digital health platform that helps in weight management and behaviour change. Combining the power of AI, mobile tech, and psychology with the empathy of 2,500+ personal coaches. Noom helps people live healthier lives by changing their long-term habits. The Noom platform is already being used by various healthcare and pharmaceutical companies to improve treatment outcomes for patients worldwide. In May 2021, Noom secured a ~$540M Series F funding led by Silver Lake to accelerate the expansion of its digital health platform in a wide range of neurologic conditions.

Founded Year: 2011

Headquarters: California, US

Total Employees: ~500

Therapy Areas: Metabolic, Endocrine, Metabolic, Neurology, Musculoskeletal

Omada is a digital health care provider that offers innovative and clinically effective digital health programs to empower individuals to engage in their health and lead healthier lives. The company combines the latest clinical protocols with breakthrough behaviour science to make it possible for people with chronic conditions to achieve long-term improvement in their health. In Apr 2021, Omada launched Physician-Guided Care, a virtual cardiometabolic clinic that provides virtual consultations with physicians for patients dealing with diabetes and hypertension. 

Founded Year: 2015

Headquarters: New York, US

Total Employees: ~200

Therapy Areas:  Metabolic, Endocrine

One Drop is a digital health company that provides a diabetes management platform to help people navigate diabetes together. The mobile app for diabetes management harnesses the power of behavioural science, mobile computing, and data science to transform the lives of people with diabetes and other chronic conditions globally. It allows users with type1, type2, or pre-diabetes to log various information: glucose, diet, activity, and insulin. In Oct 2021 One Drop in collaboration with Bayer launched its first co-developed digital product, an AI-enabled cardiovascular disease (CVD) prevention module to expand into a wide range of therapeutic areas.

Founded Year: 2013

Headquarters: Massachusetts, US

Total Employees: ~300

Therapy Areas:  Neurology

Pear Therapeutics is a healthcare company pioneering a new class of software-based medicines that are Prescription Digital Therapeutics (PDTs). The company aims to redefine medicine by discovering, developing, and delivering clinically validated software-based therapeutics to provide better outcomes for patients, smarter engagement and tracking tools for clinicians, and cost-effective solutions for payers. In Jun 2021, Pear Therapeutics reverse merged with Thimble Point Acquisition. Through this collaboration, the company enhanced the use of its prescription digital therapeutics (PDTs) among patients to treat serious diseases  

Founded Year: 1989

Headquarters: California, US

Total Employees: ~8,000

Therapy Areas:  Neurology, Respiratory

ResMed is a digital health and medical device company that develops a cloud-connected medical device that transforms care for people with sleep apnoea, COPD, and other chronic diseases. The company has developed several products for SDB and other respiratory disorders including airflow generators, diagnostic products, mask systems, headgear, and other accessories. In Oct 2021, ResMed acquired Ectosense to boost its Sleep and Respiratory Care by commercializing Ectosense’s Night Owl technology for the treatment of sleep apnoea   

Founded Year: 2015

Headquarters: New York, US

Total Employees: ~465

Therapy Areas:  Musculoskeletal

Sword Health is a digital health company that provides a digital musculoskeletal care solution. The company’s clinical-grade virtual therapy platform pairs expert physical therapists with FDA-listed wearable technology to deliver a personalized treatment plan that is more effective, easier, and less expensive than traditional physical therapy. It offers AI-powered physical therapists enabling both patients to have sessions at home and get real-time biofeedback and therapists to monitor the progress of patients. In Oct 2021, Swords Health acquired Vigilant Technology to provide acute, chronic, post-surgical, and preventative MSK care musculoskeletal (MSK) solutions through VIT’s wearable devices.

Founded Year: 2014

Headquarters: San Francisco, US

Total Employees: ~379

Therapy Areas:  Endocrine/Metabolic Diseases, Cardiovascular

Virta is a healthcare company that develops treatment for the reversal of type 2 diabetes without medication or surgery. The company provides the first clinically-proven treatment to safely and sustainably reverse type 2 diabetes and other chronic metabolic diseases. Virta uses a digital platform to help users regulate their blood sugar and eliminate the need for diabetes medications. In Apr 2021, Virta raised $133M of equity financing led by Tiger Global to accelerate its telehealth-powered diabetes reversal treatment.  

Related Post: Top 20 Innovative Digital Therapeutics Companies of 2020


Smriti

Smriti is a Senior Editor at PharmaShots. She is curious and very passionate about recent updates and developments in the life sciences industry. She covers Biopharma, MedTech, and Digital health segments along with different reports at PharmaShots. She can be contacted at smriti@pharmashots.com.

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