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Merck Reports P-III (VICTOR) Trial Data of Verquvo (Vericiguat) for Chronic Heart Failure and Reduced Ejection Fraction (HFrEF)

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  • Merck has reported P-III (VICTOR) trial data assessing Verquvo (n=3,053) vs PBO (n=3,052) in pts with stable chronic heart failure & reduced ejection fraction
  • Trial did not meet its 1EPs of reducing CV death or HF hospitalization (18% vs 19.1%); however, 2EPs showed numerically lower rates of CV death (9.6% vs 11.3%) & HF hospitalization (11.4% vs 11.9%)
  • Although, pooled analysis of P-III (VICTOR & VICTORIA) trials (n=11,155) showed Verquvo reduced risk of the composite endpoint & its secondary components across a broad HF population; both analyses were presented at ESC’25 & published in The Lancet

Ref: Merck  | Image: Merck | Press Release

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