Tags : HFrEF

Boehringer Ingelheim and Eli Lilly Report Results of Jardiance in

Shots: The companies present the findings from a new exploratory sub-analysis of the P-III EMPEROR-Reduced study demonstrating that Jardiance (empagliflozin) reduced the risk of adverse CV by 25% and kidney events by 50% in adults with HFrEF with/out diabetes regardless of CKD status at ASN Week 2020 In all patient cohorts participating in the EMPEROR-Reduced […]Read More

Merck and Bayer Receive the US FDA’s Priority Review for

Shots: The NDA is based on P-III VICTORIA study assessing vericiguat (qd, (titrated up to 10mg) vs PBO when given in combination with available HF therapies in ~5,050 patients with worsening CHF, reduced left VEF of <45% within 12mos. prior to randomization following a decompensation event The 1EPs is the composite of time to the […]Read More

Novartis Reports Results of Entresto (sacubitril/valsartan) in Three P-III PARAGON-HF

Shots: The P-III PARAGON-HF study involves assessing of Entresto vs valsartan in 4,822 HF patients with preserved ejection fraction, resulted in 13% reduction in HF hospitalization and CV death, 15% reduction in total HF hospitalization but narrowly missed the statistical significance, patients with left ventricular ejection fraction ≤57% median showed greater effect The P-IV PROVE-HF […]Read More