Shots:
- Health Canada has approved neoadj. Keytruda followed by adj. Keytruda + SoC radiotherapy (RT) ± cisplatin & then as a single agent to treat operable LA-HNSCC tumors expressing PD-L1 (CPS ≥1)
- Approval was based on P-III (KEYNOTE-689) trial assessing neoadj. Keytruda (200mg, IV, Q3W × 2 cycles), followed by adj. Keytruda (15 cycles) + SoC RT ± cisplatin vs adj. SoC RT ± cisplatin in above pts (n=714)
- Trial showed EFS risk reduction by 30%, with of mEFS: 59.7 vs 29.6mos. at first interim analysis
Ref: Merck| Image: Merck | Press Release
Related News:- Merck and Pfizer Report Topline P-III (KEYNOTE-905) Trial Finding on Keytruda + Padcev to Treat Muscle-Invasive Bladder Cancer (MIBC)
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