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AstraZeneca’s Calquence (Acalabrutinib) Plus Chemoimmunotherapy Receives the CHMP’s Positive Opinion for 1L Mantle Cell Lymphoma (MCL)

Shots:

  • The CHMP has recommended Calquence + bendamustine & rituximab for the treatment of 1L MCL adults, who are ineligible for autologous HSCT; regulatory review is ongoing in Japan & other regions
  • Opinion was based on P-III (ECHO) trial assessing the combination vs SoC (bendamustine & rituximab) in 1L MCL pts (≥65yrs.; n=635), which showed improved PFS of 27%, with mPFS of 66.4 vs 49.6mos.; data was presented at EHA 2024
  • Calquence (BTK inhibitor, BID, PO) is being evaluated as a monotx. & in combination with SoC chemoimmunotherapy for multiple B-cell blood cancers, incl. CLL, MCL & diffuse LBCL

Ref: AstraZeneca | Image: AstraZeneca

Related News:- AstraZeneca to Highlight Tagrisso’s Clinical Data for NSCLC at ELCC 2025

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