Kite Reports P-II Study (ALYCANTE) Results of Yescarta (axicabtagene ciloleucel) for Relapsed/Refractory Large B-Cell Lymphoma
- The P-II study evaluated Yescarta as 2L therapy vs SoC in 62 patients with r/r LBCL deemed ineligible for HDCT & ASCT. The study was led & sponsored by the French collaborative group LYSA/LYSARC
- The study met its 1EPs & showed a complete metabolic response (71% vs 12%) at 3mos., 59.7% remained in CMR at 6mos., best OR (91.9%) & CR rates (82.3%), m-PFS from infusion (11.8mos.) after a median follow-up of 12mos., 48.8% were alive and progression-free at 12mos.
- m-OS (not reached), OS was 78.3% at 12mos. & showed an acceptable safety profile in this population considered unfit for HDCT/ASCT while 8.1% & 14.5% experienced grade 3-4 CRS or ICANS, respectively. The results were published in Nature Medicine
Ref: Kite | Image: Kite
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