Kite Reports P-III Study (ZUMA-7) Results of Yescarta for Initial Treatment of Relapsed/Refractory Large B-cell Lymphoma
- The P-III study (ZUMA-7) evaluated Yescarta vs SoC in a ratio (1:1) in 359 patients with r/r LBCL within 12mos. at 77 centers globally
- The results showed an improvement in OS over historical treatment, a 2.5-fold increase in patients (40.5% vs 16.3%) who were alive @2yrs. and did not experience cancer progression or need additional cancer treatment and a 4-fold greater m-EFS (8.3 vs 2.0mos.)
- Patients responded to Yescarta, ORR (83% vs 50%) & CR rate (65% vs 32%), ≥50% in the SOC arm received Yescarta off study at the time of the primary EFS analysis. The safety profile was consistent with prior studies, grade ≥3 CRS & neurologic events were seen in 7% & 25% while 83% had high-grade events in the SOC arm
Ref: Businesswire | Image: Kite
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