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How Does SIGMAR1 Recombinant Protein Help Study Alzheimer’s Disease?

Neurons are specialized nerve cells in the brain and nervous system that continuously communicate. At the same time, our brain produces and clears proteins, mitochondria generate energy, and the endoplasmic reticulum (ER) maintains protein and calcium balance. These processes work together to keep neurons healthy and functioning properly.  However, when this cellular balance is disrupted,…

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Inside Anavex’s Alzheimer’s Strategy: Dr. Christopher Missling on Blarcamesine, SIGMAR1, and Precision Medicine 

Shots:   Neurodegenerative care is at a pivotal inflection point, shifting from symptomatic relief to strategies that restore cellular resilience. Blarcamesine (ANAVEX 2-73) advances this upstream approach by activating SIGMAR1 to rebalance autophagy, targeting a core driver of neurodegeneration  Phase IIb/III findings demonstrated a statistically significant slowing of cognitive decline, with the most pronounced benefit seen in patients carrying the…

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