Shots:
The EC has approved Redemplo as an adjunct to diet to reduce triglycerides (TGs) in adults with Familial Chylomicronemia Syndrome (FCS), backed by the P-III (PALISADE) trial assessing it (25 & 50mg, SC, Q3M) vs PBO in 75 FCS adults
Trial met its 1 & all multiplicity-controlled key 2EPs. 25mg showed an 80% vs…
Shots:
Ionis has reported P-III (CORE: n=617 & CORE2: n=446) trials data assessing olezarsen (50 or 80mg, SC, Q4W) vs PBO for 12mos. in adults with severe hypertriglyceridemia (sHTG); the US FDA’s sNDA submission expected by year end
Both studies met their 1EP, with CORE showing reduction in fasting triglycerides by 72% (80mg) & 63%…

