Shots:
The EMA has granted ODD to rilzabrutinib for the treatment of IgG4-related disease (IgG4-RD)
Rilzabrutinib (PO) is being evaluated in a P-II trial for IgG4-RD with glucocorticoids vs glucocorticoids alone, showing reduced flares, improved disease markers, & steroid sparing over 52 weeks; data presented at EULAR 2025
Rilzabrutinib, a reversible covalent BTK inhibitor, is…
Shots:
The P-II (WILLOW) basket trial assessed enpatoran (25, 50 &100mg, BID, PO) vs PBO + SoC in 2 Arms, where Arm 1 has SLE & CLE pts with active lupus rash & Arm 2 has active SLE pts. Discussions with health authorities on a global P-III program are underway
Arm 1 met its 1EP,…

