Tokyo, Japan and Cambridge, UK, 31 October 2023 – Sosei Group Corporation (“Sosei Heptares” or “the Company”; TSE: 4565) will receive a US$3.75 million milestone payment under the 2019 multi-target Research Collaboration and License Agreement with Genentech, a member of the Roche Group. The discovery-based payment is related to progression of a potential first-in-class project targeting an undisclosed G protein-coupled receptor (“GPCR”). Genentech will now be responsible for further development and commercialization of this potential new medicine.

This milestone is the latest of an ongoing collaboration that utilizes Sosei Heptares’ proprietary GPCR-focused structure-based drug design capabilities combined with Genentech’s discovery, development and therapeutic area expertise directed towards multiple GPCR targets nominated by Genentech.

Under the terms of the agreement, Sosei Heptares is eligible to receive future milestone payments from Genentech, which in total may exceed US$1 billion upon achieving pre-specified research, development and commercialization events.

Dr. Matt Barnes, President of Heptares Therapeutics and Head of UK R&D at Sosei Heptares, said: “We are extremely pleased to see the progression of this novel first-in-class project. The insight and expertise from both companies from target selection and drug discovery is a truly exciting combination and further demonstrates the productivity of our structure-based drug design platform. We look forward to further achievements from this successful partnership.”

The milestone payment will be recognized as revenue in the fourth quarter of the financial year ending 31 December 2023.

-ENDS-

About the agreement with Genentech

Sosei Heptares and Genentech entered into a multi-target research collaboration and license agreement in July 2019, to discover and develop novel medicines (new small molecules and/or biologics) that modulate G protein-coupled receptor (GCPR) targets. Under the terms of the agreement, Sosei Heptares is eligible to receive future milestone payments from Genentech, which in total may exceed US$1 billion upon achieving pre-specified research, development and commercialization events. Additionally, the Company is eligible to receive royalty payments on the net sales of potential future medicines arising from the collaboration. Genentech is responsible for developing and commercializing potential new medicines for each novel target and has exclusive global rights to these agents. Further details of the agreement can be found by clicking here.

Our global business combines our world-leading GPCR-targeted StaR® technology, structure-

based drug design and early development capabilities in the UK with a highly experienced clinical development capability and a commercial operation in Japan.

We are leveraging these capabilities to generate and advance a broad and deep pipeline of novel medicines across multiple therapeutic areas, including neurology, immunology, gastroenterology and inflammatory diseases. We intend to develop these opportunities for patients in Japan and globally both internally and through our partnerships with global biopharmaceutical companies and emerging technology companies.

Sosei Heptares operates from key locations in Tokyo and Osaka (Japan), London and Cambridge (UK), Basel (Switzerland) and Seoul (South Korea).

“Sosei Heptares” is the corporate brand and trademark of Sosei Group Corporation, which is listed on the Tokyo Stock Exchange (ticker: 4565). Sosei, Heptares, the logo and StaR® are trademarks of Sosei Group companies.

For more information, please visit https://soseiheptares.com/

LinkedIn: @soseiheptaresco | Twitter: @soseiheptaresco | YouTube: @soseiheptaresco

Enquiries:

Sosei Heptares – Media and Investor Relations

Kentaro Tahara, VP Investor Relations and Corporate Strategy

Shinichiro Nishishita, VP Investor Relations, Head of Regulatory Disclosures Maya Bennison, Communications Manager

+81 (0)3 5210 3399 | +44 (0)1223 949390 | IR@SoseiHeptares.com

MEDiSTRAVA Consulting (for International Media)

Mark Swallow, Frazer Hall, Erica Hollingsworth

+44 (0)203 928 6900 | SoseiHeptares@medistrava.com

Source:- Sosei Heptares