Regulation FD Disclosure
[caption id="attachment_9277" align="alignleft" width="1079"] Press Release[/caption]
On December 30, 2019, Aridis Pharmaceuticals, Inc. (the ?Company?) announced the development of a novel monoclonal antibody (?mAb?)
discovery, antibody production and yield maximizing technology called APEX
TM and a collaboration with Mapp Biopharmaceutical, Inc, a company
incorporated in the U.S. (?MappBio?).
APEX
TM is a technology suite comprising of a monoclonal antibody discovery platform technology that enables the screening and single cell
cloning of antibody producing B-cells using microarrays (?APEX
TM NanoArrays?), a proprietary mAb cell line technology called BREATH
TM CHO that
enables gene editing-assisted gene swapping of the candidate antibody genes with endogenous versions to generate a high mAb productivity cell line, and a
gene editing-based technology to activate endogenous genes in antibody production cell lines to increase mAb production. A schematic representation of
APEX
TM is shown in figure below
APEX
TM builds upon the Company?s original hybridoma-based technology platform, MabIgX
?, which allows for rapid fusion and production of
mAbs directly from patients antibody-producing B-cells.
MappBio agreed to enter into research collaborations with the Company whereby the Company will apply its APEX
TM technology to develop mAb
productivity enhanced versions of an undisclosed number of CHO cell lines that were originally developed by MappBio.
The information in this Item 7.01 shall not be deemed ?filed? for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the ?Exchange
Act?), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as
amended, or the Exchange Act, except as expressly set forth by specific reference in such a filing