Novartis Kisqali receives the highest rating of any CDK4/6 inhibitor on the ESMO Magnitude of Clinical Benefit Scal
Sep 21, 2020
- Kisqali is the only CDK4/6 inhibitor, in combination with endocrine therapy, to achieve a perfect 5 out of 5 score ? confirming substantial benefit for premenopausal women with HR+/HER2- advanced breast cancer (aBC), based on significant overall survival (OS) benefit and improved quality of life, in the MONALEESA-7 study1
- Kisqali is also the only CDK4/6 inhibitor to receive a score of 4 out of 5 for first-line postmenopausal women with HR+/HER2- aBC based on the OS benefit and maintained quality of life observed in MONALEESA-32
- New data at ESMO Virtual Congress 2020 add to the substantial body of evidence further differentiating Kisqali as the only CDK 4/6 inhibitor that significantly improves OS in two phase III trials, with consistent results across patient subgroups, and with quality of life benefits
- An analysis that found Kisqali plus endocrine therapy demonstrated consistent improvement in overall survival in patients with endocrine-resistant HR+/HER2- advanced breast cancer, which is typically more challenging to treat. Treatment with Kisqali in patients with endocrine resistance led to a 30% and 41% reduction in the risk of death in the MONALEESA-3 and -7 studies over standard endocrine therapy, respectively. Safety was consistent with the overall study populations in both trials4.
- An oral presentation of a robust pooled analysis of patient-reported outcomes from MONALEESA-2, -3, and -7 trials in first-line patients, which demonstrated improvement in quality of life for patients with HR+/HER2- advanced breast cancer upon receiving Kisqali plus endocrine therapy with consistency in different subgroups analyzed5.
- A matching-adjusted indirect comparison (MAIC), a method used to estimate the comparative effectiveness of treatments after adjusting for differences in the patient populations where head-to-head trials do not exist, indicated that patients taking Kisqali plus fulvestrant as first-line therapy may live significantly longer than those taking palbociclib plus letrozole, based on the MONALEESA-3 and PALOMA-1 trials, respectively6. A trend toward improved progression free survival (PFS) for Kisqali plus fulvestrant versus palbociclib plus letrozole was also observed.
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Novartis Media Relations E-mail:?media.relations@novartis.comAnja von Treskow Novartis External Communications +41 79 392 8697 anja.von_treskow@novartis.com Eric Althoff Novartis US External Communications +1 646 438 4335 eric.althoff@novartis.com | Julie Masow Novartis Oncology Media Relations +1 862 579 8456 julie.masow@novartis.com |
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