Breztri Aerosphere reduced rate of COPD exacerbations across all seasons compared with Bevespi Aerosphere

AstraZeneca to present 60 abstracts from inhaled and biologics portfolio and pipeline at the ERS Congress

A post-hoc analysis of the Phase III ETHOS trial showed a consistent benefit of?Breztri Aerosphere?(budesonide/glycopyrronium/formoterol fumarate) in reducing the rate of moderate or severe chronic obstructive pulmonary disease (COPD) exacerbations across all seasons compared with?Bevespi Aerosphere?(glycopyrronium/formoterol fumarate) in patients with moderate to very severe disease.¹ These data are among 60 AstraZeneca abstracts accepted for presentation, including 10 oral presentations, at the European Respiratory Society (ERS) International Virtual Congress 2020, between 7-9 September. Gary Ferguson, Clinical Professor of Medicine at Michigan State University, Director of the Pulmonary Research Institute of Southeast Michigan, Farmington Hills, Michigan, US and Investigator in the ETHOS trial, said: ?Treating patients with chronic obstructive pulmonary disease can be challenging in the winter as they experience more frequent and more severe exacerbations, contributing to increased morbidity and mortality. Results from the ETHOS trial should give clinicians confidence that they can reduce moderate or severe exacerbations, even during winter when respiratory diseases can put additional strain on healthcare systems.? Ruud Dobber, Executive Vice President, BioPharmaceuticals Business Unit, said: ?These additional data from the Phase III?ETHOS trial are important in supporting clinicians? understanding of the robust clinical profile of?Breztri Aerosphere, which has been approved in the US, China and Japan and is under regulatory review in the EU. With 60 company abstracts accepted for presentation at ERS, there is a wealth of data across AstraZeneca?s inhaled combinations and biologic medicines, which demonstrates our commitment to advancing clinical practice in respiratory disease.? AstraZeneca abstracts to be presented at the ERS International Congress 2020 include: Breztri Aerosphere

• Seasonal variation in COPD exacerbation rates: budesonide/glycopyrronium/formoterol metered dose inhaler (BGF MDI) at two ICS dose levels in the ETHOS trial (Oral presentation: Abstract OA5238, Wednesday 09 September 16:50-17:50 CEST)
• Exacerbation benefit by blood eosinophil counts with budesonide/glycopyrronium/formoterol metered dose inhaler (BGF MDI) at two ICS dose levels in the ETHOS trial: a subgroup analysis (E-poster session: Abstract PA984, Monday 24 August)

Symbicort Turbuhaler?(budesonide/formoterol)

• LATE BREAKER: Reimbursement for asthma care is a universal barrier to achieving asthma symptom control: The SABINA III study (E-poster session: Abstract PA2665, Monday 24 August)
• LATE BREAKER: Short-Acting ?2-Agonist Use in Asthma in Western Societies (E-poster session: Abstract PA2629, Monday 24 August)
• Efficacy of as-needed budesonide/formoterol in mild asthma: pooled analysis of SYGMA 1 and 2 (E-poster session: Abstract PA2275, Monday 24 August)

Fasenra?(benralizumab)

• Real-world treatment?patterns of?benralizumab?therapy for patients with?severe asthma. (Oral presentation: Abstract OA4646, Tuesday 08 September 15:40-16:40 CEST)
• LATE BREAKER: Benralizumab in severe asthma: preliminary results from the Italian ANANKE study (E-poster session: Abstract PA2609, Monday 24 August)

Tezepelumab

• Efficacy of tezepelumab in patients with low and high bronchodilator reversibility in PATHWAY (E-poster session: Abstract PA2269, Monday 24 August)

Early science

• Profiling the impact of two JAK inhibitors (AZD0449 & AZD4604) in a pre-clinical model of allergic asthma (E-poster session: Abstract PA3302, Monday 24 August)

COPD COPD is a progressive disease which can cause obstruction of airflow in the lungs resulting in debilitating bouts of breathlessness.^2?It affects an estimated 384 million people³?and is the third leading cause of death globally.⁴?Improving lung function, reducing exacerbations and managing daily symptoms such as breathlessness are important treatment goals in the management of COPD.²?A single COPD exacerbation can have a negative impact on lung function⁵, quality of life⁶?and increase the risk of hospitalisation.⁷?Additionally, even one COPD exacerbation that results in hospitalisation, increases the risk of death.^8,9 Patients with COPD experience an increase in incidence of exacerbations and severe exacerbations during the winter.^10,11?Studies have also shown higher rates of COPD hospital admissions and more respiratory-related deaths in winter compared with summer months.^10-13? ETHOS ETHOS is a randomised, double-blind, multi-centre, parallel-group, 52-week trial to assess the efficacy and safety of?Breztri Aerosphere?in symptomatic patients with moderate to very severe COPD and a history of exacerbation(s) in the previous year. The primary endpoint was the rate of moderate or severe exacerbations. Results were published in the?New England Journal of Medicine.¹⁴ Breztri Aerosphere Breztri Aerosphere?(budesonide/glycopyrrolate/formoterol fumarate) is a single-inhaler, fixed dose triple-combination of budesonide, an inhaled corticosteroid (ICS), with glycopyrrolate, a long-acting muscarinic antagonist (LAMA), and formoterol fumarate, a long-acting beta2-agonist (LABA), delivered in a pressurised metered-dose inhaler. AstraZeneca in Respiratory & Immunology Respiratory & Immunology is one of AstraZeneca?s three therapy areas and is a key growth driver for the Company. Building on a 50-year heritage,?AstraZeneca is an established leader in respiratory care, across inhaled and biologic medicines. AstraZeneca aims to transform the treatment of asthma and COPD by eliminating preventable asthma attacks across all severities and removing COPD as a leading cause of death through earlier biology-led treatment.?The Company?s early respiratory research is focused on emerging science involving immune mechanisms, lung damage and abnormal cell-repair processes in disease and neuronal dysfunction. With common pathways and underlying disease drivers across respiratory and immunology, AstraZeneca is following the science from chronic lung diseases to immunology-driven disease areas. The Company?s growing presence in immunology is focused on five mid- to late-stage franchises with multi-disease potential in rheumatology (including systemic lupus erythematosus), dermatology, gastroenterology, and systemic eosinophilic-driven diseases. AstraZeneca?s ambition in immunology is to achieve disease control and ultimately clinical remission in targeted immune-driven diseases. AstraZeneca AstraZeneca (LSE/STO/NYSE: AZN) is a global, science-led biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines, primarily for the treatment of diseases in three therapy areas - Oncology, Cardiovascular, Renal and Metabolism, and Respiratory & Immunology. Based in Cambridge, UK, AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. Please visit?astrazeneca.com?and follow the Company on Twitter?@AstraZeneca. Contacts For details on how to contact the Investor Relations Team, please click?here. For Media contacts, click?here.

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