Medicago and GSK announce positive interim Phase 2 results for adjuvanted COVID-19 vaccine candidate

About Phase 2: Results Summary
The interim data from Phase 2 in adults and in the elderly have been published on an online preprint server at?MedRxiv.- This publication focuses on presenting safety and tolerability results, and immunogenicity, as measured by neutralizing antibody (NAb) and cell mediated immunity (IFN-? and IL-4 ELISpot) responses, in adults aged 18-64 (adults) and older adults aged 65+ (older adults).
- Medicago?s vaccine candidate with GSK?s pandemic adjuvant exhibited an acceptable safety profile and adverse events (AEs) were primarily mild or moderate and of transient duration.
- AEs in older adults were more limited than those observed in the adult population.
- Medicago?s vaccine candidate with GSK?s pandemic adjuvant induced a significant humoral immune response of similar strength in both age cohorts after two doses.
- The vaccine candidate induced a greater humoral response in adults than older adults after a single dose but after the second dose both age cohorts responded with NAb titers that were about 10 times higher than those in a panel of sera from patients recovering from COVID-19.