Jardiance^??(empagliflozin) reduced the risk for the composite primary endpoint of cardiovascular death or hospitalization for heart failure and slowed kidney function decline in adults with heart failure with left ventricular ejection fraction (LVEF) over 40% regardless of chronic kidney disease status at baseline, according to findings from a new prespecified sub-analysis of the EMPEROR-Preserved^??phase III trial. In EMPEROR-Preserved, two thirds of enrolled adults had heart failure with preserved ejection fraction (HFpEF; LVEF of at least 50%) and one third had mildly reduced LVEF (greater than 40% but less than 50%). The results were presented today at the?American Society of Nephrology Kidney Week?2021,?Boehringer Ingelheim?and?Eli Lilly and Company?(NYSE: LLY) announced. "Heart failure and chronic kidney disease are intimately linked ? the risk of death in people with heart failure increases with kidney function decline,"?said Faiez Zannad, M.D., Ph.D.,?EMPEROR Program?clinical investigator and Emeritus Professor of Therapeutics and Cardiology at the?University of Lorraine,?France. "The consistent benefits shown for the reduction of serious heart failure events and the slowing of kidney function decline regardless of chronic kidney disease status are welcome results for both patients and physicians. The findings underscore the potential value of empagliflozin across a wide range of kidney function in this heart failure population that includes people with preserved ejection fraction." Nearly half of adults with heart failure also have chronic kidney disease. Together, these conditions are associated with high mortality rates and risk for hospital admission. More than 6 million people in the?U.S.?have heart failure, and approximately half of them have HFpEF. No currently approved treatments have been clinically proven to significantly improve outcomes across the full spectrum of heart failure. "Heart failure, especially with preserved ejection fraction, is a complex, difficult-to-treat condition, and the prognosis only worsens with the combined burden of chronic kidney disease," said?Mohamed Eid, M.D., M.P.H, M.H.A, vice president,?Clinical Development & Medical Affairs, Cardio-Metabolism & Respiratory Medicine,?Boehringer Ingelheim Pharmaceuticals, Inc.?"The encouraging results from this sub-analysis further demonstrate the potential for Jardiance to offer a treatment option for adults with cardio-renal-metabolic conditions." As previously reported, EMPEROR-Preserved showed that Jardiance significantly reduced the risk for the composite primary endpoint of cardiovascular death or hospitalization for heart failure in adults with heart failure with LVEF over 40% compared with placebo. Jardiance also significantly reduced the risk of first and recurrent hospitalizations for heart failure and slowed kidney function decline. Over half (53.5%) of adults in EMPEROR-Preserved had chronic kidney disease (defined as eGFR below 60 mL/min/1.73 m²?or UACR above 300 mg/g)?at trial entry, and 9.7% had severe kidney impairment (eGFR below 30 mL/min/1.73 m²). The new prespecified sub-analysis of EMPEROR-Preserved demonstrated that the benefits seen in the overall population were consistent in adults with and without chronic kidney disease.?Jardiance consistently improved cardiovascular outcomes and slowed kidney function decline across the full range of kidney function down to an eGFR of 20 mL/min/1.73 m². Jardiance was well tolerated regardless of the level of baseline kidney function. "This data marks an important milestone for the growing number of people living with both heart failure and chronic kidney disease, many of whom are in need of additional treatment options for these interconnected, complex conditions," said?Jeff Emmick, M.D., Ph.D., vice president, Product Development,?Lilly. "We look forward to continuing research with the goal of addressing the unmet needs of those with kidney impairment, including through our EMPA-KIDNEY phase III trial of Jardiance, from which we eagerly await a readout next year." The?U.S. Food and Drug Administration?(FDA) previously granted Fast Track designation for the development of Jardiance to reduce the risk of cardiovascular death and hospitalization for heart failure in adults with chronic heart failure (New York Heart?Association [NYHA] Class II-IV). The Fast Track designation is for the EMPEROR program, which consists of the EMPEROR-Reduced^??and EMPEROR-Preserved trials. The EMPEROR-Reduced results formed the basis of the recent FDA approval for heart failure with reduced ejection fraction. Based on results from EMPEROR-Preserved, the FDA granted Breakthrough Therapy designation for Jardiance as an investigational treatment for adults with HFpEF. Jardiance is not indicated for the treatment of HFpEF. In?March 2020, the FDA also granted Fast Track designation to Jardiance for the treatment of chronic kidney disease. This designation covers the ongoing EMPA-KIDNEY trial, which is investigating the effect of Jardiance on the progression of kidney disease and occurrence of cardiovascular death in adults with established chronic kidney disease, with and without diabetes. Jardiance is not indicated for the treatment of chronic kidney disease. About EMPEROR-Preserved EMPEROR-Preserved?(NCT03057951) was a phase III international, randomized, double?blind trial that enrolled 5,988 adults with and without type 2 diabetes. All participants had heart failure (New York Heart?Association [NYHA] functional class II, III or IV) and LVEF over 40%; 4,005 (67%) had HFpEF (LVEF of at least 50%), and 1,983 (33%) had mildly reduced LVEF (greater than 40% but less than 50%). Participants were randomized to once-daily Jardiance 10 mg (n=2997) or placebo (n=2991), on top of treatment with guideline-directed heart failure therapy. Median follow-up time was 26.2 months. The composite primary endpoint was defined as time to first event of cardiovascular death or hospitalization for heart failure. About the EMPOWER program The Alliance has developed the EMPOWER program to explore the impact of Jardiance on major clinical cardiovascular and renal outcomes in a spectrum of cardio-renal-metabolic conditions. Cardio-renal-metabolic conditions are the leading cause of mortality worldwide and account for up to 20 million deaths annually. Through the EMPOWER program,?Boehringer Ingelheim?and?Lilly?are working to advance knowledge of these interconnected systems and create care which offers integrated, multi-organ benefits. Comprised of nine clinical trials and two real-world evidence studies, EMPOWER reinforces the long-term commitment of the Alliance to improve outcomes for people living with cardio-renal-metabolic conditions. With more than 400,000 adults enrolled worldwide in clinical trials, it is one of the broadest and most comprehensive clinical programs for an SGLT2 inhibitor to date. The development program encompasses:

• EMPEROR-Reduced, in adults with chronic heart failure with reduced ejection fraction to reduce the risk of cardiovascular death or hospitalization due to heart failure
• EMPEROR-Preserved, in adults with chronic heart failure with preserved ejection fraction to reduce the risk of cardiovascular death or hospitalization due to heart failure
• EMPULSE, in adults hospitalized for acute heart failure and stabilized to improve clinical and patient reported outcomes
• EMPACT-MI, to evaluate all-cause mortality and hospitalization for heart failure in adults with and without type 2 diabetes who have had an acute myocardial infarction, with the aim to prevent heart failure and improve outcomes
• EMPA-KIDNEY, in adults with established chronic kidney disease to reduce the progression of kidney disease and the occurrence of cardiovascular death
• EMPERIAL-Reduced, in adults with chronic heart failure with reduced ejection fraction to evaluate functional ability and patient-reported outcomes
• EMPERIAL-Preserved, in adults with chronic heart failure with preserved ejection fraction to evaluate functional ability and patient-reported outcomes
• EMPA-REG OUTCOME^?, in adults with type 2 diabetes and established cardiovascular disease to reduce the risk of major adverse cardiovascular events, including cardiovascular death
• EMPRISE, two non-interventional studies (U.S.?and EU-Asia) of the effectiveness, safety, healthcare utilization and cost of care of empagliflozin in routine clinical practice in adults with type 2 diabetes across the cardiovascular risk continuum

Prioritizing Cardio-Renal-Metabolic Care Through research and educational initiatives,?Boehringer Ingelheim?and?Lilly?are driven to redefine?care for people with cardio-renal-metabolic conditions, a group of interconnected disorders that affect more than one billion people worldwide and are a leading cause of death. The cardiovascular, renal (kidney) and metabolic systems are closely intertwined?and share many of the same disease-related?pathways.?Dysfunction in one system may accelerate the onset of dysfunction in others, resulting in the progression of comorbid?diseases such as type 2 diabetes, heart failure and chronic kidney disease. Conversely, improving the health of?one system can lead to positive effects across?the others?and can help reduce the risk for further complications. Understanding their interconnected nature, we are working to advance treatments for people with cardio-renal-metabolic conditions. It?is only through a holistic approach to care that we can truly transform outcomes?and restore the harmony between these critical systems. What?is?JARDIANCE??(www.jardiance.com) JARDIANCE is?a prescription?medicine used to:

• lower blood sugar along with diet and exercise in adults with type 2 diabetes
• reduce the risk of cardiovascular death in adults with type 2 diabetes who also have known cardiovascular disease
• reduce the risk of cardiovascular death and hospitalization for heart failure (when the heart is weak and cannot pump enough blood to the rest of your body) in adults with heart failure

JARDIANCE?is?not?for?people?with type 1 diabetes. It may increase their risk of diabetic ketoacidosis?(increased ketones?in?the blood or urine). JARDIANCE is not for use to lower blood sugar in adults with type 2 diabetes who have severe kidney problems, because it may not work. IMPORTANT?SAFETY?INFORMATION Do?not?take?JARDIANCE?if you?are allergic?to empagliflozin?or?any?of the ingredients?in JARDIANCE. Do?not?take?JARDIANCE?if you are on?dialysis. JARDIANCE?can?cause?serious?side?effects,?including:

• Ketoacidosis (increased ketones in your blood or urine).?Ketoacidosis is a serious condition which needs to be treated in the hospital. Ketoacidosis may lead to death. Ketoacidosis occurs in people with type 1 diabetes and can also occur in people with type 2 diabetes taking JARDIANCE,?even if blood sugar is less than 250 mg/dL. Ketoacidosis has also happened in people with diabetes who were sick or who had surgery during treatment with JARDIANCE.?Stop taking JARDIANCE and call your healthcare provider right away or go to the nearest hospital emergency room if you get any of the following symptoms,?and if possible, check for ketones in your urine:
  • nausea
  • vomiting
  • stomach-area (abdominal) pain
  • tiredness
  • trouble breathing
• Dehydration.?JARDIANCE?can?cause some people to become dehydrated?(the loss?of?body?water?and salt). Dehydration?may?cause you to feel dizzy, faint,?light-headed, or?weak,?especially?when?you stand up. Sudden worsening of kidney function has happened in people who are taking JARDIANCE. You may?be at?a higher?risk?of?dehydration?if you:
  • take medicines?to lower?your?blood pressure, including?water?pills?(diuretics)
  • are?on?a low?salt?diet
  • have?kidney?problems
  • are?65 years?of?age or?older

Talk to your healthcare provider about what you can do to prevent dehydration, including how much fluid you should drink on a daily basis, and if you reduce the amount of food or liquid you drink, if you are sick or cannot eat, or start to lose liquids from your body from vomiting, diarrhea, or being in the sun too long.

• Serious urinary tract infections.?Serious urinary tract infections can occur in people taking JARDIANCE and may lead to hospitalization. Tell your healthcare provider if you have symptoms of a urinary tract infection, such as a burning feeling when passing urine, a need to urinate often or right away, pain in the lower part of your stomach or pelvis, or blood in the urine. Sometimes people also may have a fever, back pain, nausea or vomiting.
• Low?blood?sugar?(hypoglycemia):?If you take JARDIANCE?with another?medicine that?can?cause low?blood sugar, such as?sulfonylurea or?insulin, your?risk?of low?blood sugar?is?higher. The dose of your?sulfonylurea or?insulin?may?need?to be lowered. Symptoms?of?low?blood?sugar?may?include:
  • headache
  • drowsiness
  • weakness
  • dizziness
  • confusion
  • irritability
  • hunger
  • fast heartbeat
  • sweating
  • shaking or feeling jittery
• Necrotizing fasciitis. A rare but serious bacterial infection that causes damage to the tissue under the skin in the area between and around your anus and genitals (perineum).?This bacterial infection has happened in women and men who take JARDIANCE, and may lead to hospitalization, multiple surgeries, and death.?Seek medical attention immediately if you have fever or are feeling very weak, tired or uncomfortable (malaise), and you develop any of the following symptoms in the area between and around your anus and genitals: pain or tenderness, swelling, and redness of skin (erythema).
• Vaginal?yeast?infection.?Talk?to your?healthcare provider?if you?have vaginal odor,?white or?yellowish vaginal?discharge (discharge may?be lumpy?or?look?like cottage?cheese), and/or?vaginal?itching.
• Yeast?infection?of the penis.?Swelling of an uncircumcised penis may develop that makes it difficult to pull back the skin around the tip of the penis.?Talk?to your healthcare provider?if you have redness, itching?or?swelling?of the?penis,?rash of the penis, foul smelling discharge from?the penis,?and/or?pain?in?the skin?around the?penis. Talk to your healthcare provider about what to do if you get symptoms of a yeast infection of the vagina or penis. Your healthcare provider may suggest you use an over-the-counter antifungal medicine. Talk to your healthcare provider right away if you use an over-the-counter antifungal medication and your symptoms do not go away.
• Allergic (hypersensitivity) reactions.?Symptoms?of?serious?allergic?reactions?to JARDIANCE may?include:
  • swelling of your face, lips, throat, and other areas of your skin
  • difficulty with swallowing or breathing
  • raised, red areas on your skin (hives)

If you have any?of these symptoms,?stop?taking?JARDIANCE?and?contact?your?healthcare provider?or?go to the nearest?emergency?room?right?away. The?most?common?side?effects?of?JARDIANCE?include?urinary?tract?infections?and?yeast?infections?in females. These?are?not?all?the?possible?side?effects?of?JARDIANCE.?For?more?information,?ask?your?healthcare provider?or?pharmacist. Before taking JARDIANCE, tell?your?healthcare provider?about all of your medical conditions, including if?you:

• have kidney?problems
• have liver?problems
• have a history of infection of the vagina or penis
• have a history?of urinary?tract?infections?or?problems?with urination
• are going to have surgery. Your healthcare provider may stop your JARDIANCE before you have surgery. Talk to your healthcare provider if you are having surgery about when to stop taking JARDIANCE and when to start it again
• are eating less or there is a change in your diet
• have or have had problems with your pancreas, including pancreatitis or surgery on your pancreas
• drink alcohol very often, or drink a lot of alcohol in the short term ("binge" drinking)
• have type 1 diabetes. JARDIANCE should not be used to treat people with type 1 diabetes
• are pregnant?or?plan?to become pregnant. JARDIANCE may harm?your?unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with JARDIANCE
• are breastfeeding?or?are planning to breastfeed. JARDIANCE may pass into your?breast?milk and may harm your baby. Do not breastfeed while taking JARDIANCE

Tell?your?healthcare provider?about?all?the medicines?you take,?including?prescription?and over-the-counter medicines, vitamins, and?herbal supplements.?Especially?tell your?healthcare provider?if?you take?water?pills (diuretics)?or?medicines?that?can?lower?your?blood?sugar,?such as?insulin. You are encouraged?to?report?negative side effects?of?prescription?drugs to?the?FDA.?Visit?www.fda.gov/medwatch?or?call 1-800-FDA-1088. For?more?information,?please?see?Prescribing?Information?and?Medication Guide. CL-JAR-100093?08.18.2021 Boehringer Ingelheim?and?Eli Lilly and Company In?January 2011,?Boehringer Ingelheim?and?Eli Lilly and Company?announced an alliance that centers on compounds representing several of the largest diabetes treatment classes. Depending on geographies, the companies either co-promote or separately promote the respective molecules each contributing to the alliance. The alliance leverages the strengths of two of the world's leading pharmaceutical companies to focus on patient needs. By joining forces, the companies demonstrate their commitment, not only to the care of people with diabetes, but also to investigating the potential to address areas of unmet medical need. Clinical trials have been initiated to evaluate the impact of Jardiance on people living with heart failure or chronic kidney disease. About?Boehringer Ingelheim Making new and better medicines for humans and animals is at the heart of what we do. Our mission is to create breakthrough therapies that change lives. Since its founding in 1885,?Boehringer Ingelheim?is independent and family-owned. We have the freedom to pursue our long-term vision, looking ahead to identify the health challenges of the future and targeting those areas of need where we can do the most good. As a world-leading, research-driven pharmaceutical company, with around 52,000 employees, we create value through innovation daily for our three business areas: Human Pharma,?Animal Health, and Biopharmaceutical Contract Manufacturing. In 2020,?Boehringer Ingelheim?achieved net sales of around?22.33 billion USD?(19.57 billion EUR). Our significant investment of over?4.2 billion USD?(3.7 billion EUR) in 2020 (18.9% of net sales) in R&D drives innovation, enabling the next generation of medicines that save lives and improve quality of life. We realize more scientific opportunities by embracing the power of partnership and diversity of experts across the life-science community. By working together, we accelerate the delivery of the next medical breakthrough that will transform the lives of patients now, and in generations to come. Boehringer Ingelheim Pharmaceuticals, Inc., based in?Ridgefield, CT, is the largest?U.S.?subsidiary of?Boehringer Ingelheim Corporation?and is part of the?Boehringer Ingelheim?group of companies. In addition, there are?Boehringer Ingelheim Animal Health?in?Duluth, GA?and?Boehringer Ingelheim Fremont, Inc.?in?Fremont, CA. Boehringer Ingelheim?is committed to improving lives and strengthening our communities. Please visit?www.boehringer-ingelheim.us/csr?to learn more about Corporate Social Responsibility initiatives. For more information, please visit?www.boehringer-ingelheim.us, or follow us on Twitter @BoehringerUS. About?Lilly?Diabetes Lilly?has been a global leader in diabetes care since 1923, when we introduced the world's first commercial insulin. Today we are building upon this heritage by working to meet the diverse needs of people with diabetes and those who care for them. Through research, collaboration and quality manufacturing we strive to make life better for people affected by diabetes and related conditions. We work to deliver breakthrough outcomes through innovative solutions?from medicines and technologies to support programs and more. For the latest updates, visit?http://www.lillydiabetes.com/?or follow us on Twitter:?@LillyDiabetes?and Facebook:?LillyDiabetesUS. About Eli?Lilly?and Company? Lilly?is a global health care leader that unites caring with discovery to create medicines that make life better for people around the world. We were founded more than a century ago by a man committed to creating high-quality medicines that meet real needs, and today we remain true to that mission in all our work. Across the globe,?Lilly?employees work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to communities through philanthropy and volunteerism. To learn more about?Lilly, please visit us at?lilly.com?and?lilly.com/newsroom. This press release contains forward-looking statements (as that term is defined in the Private Securities Litigation Reform Act of 1995) about Jardiance as a treatment for adults with type 2 diabetes, to reduce the risk of cardiovascular death in adults with type 2 diabetes and known cardiovascular disease, and to reduce the risk of cardiovascular death plus hospitalization for heart failure in adults with heart failure with reduced ejection fraction, and as a potential treatment for adults with cardio-renal-metabolic conditions and reflects?Lilly's current beliefs and expectations. However, as with any pharmaceutical product, there are substantial risks and uncertainties in the process of drug research, development and commercialization. Among other things, there can be no guarantee that planned or ongoing studies will be completed as planned, that future study results will be consistent with the results to date or that Jardiance will receive additional regulatory approvals. For a further discussion of these and other risks and uncertainties that could cause actual results to differ from?Lilly's expectations, please see?Lilly's most recent Forms 10-K and 10-Q filed with the?U.S. Securities and Exchange Commission.?Lilly?undertakes no duty to update forward-looking statements. Jardiance^?, EMPEROR-Preserved^?, EMPEROR-Reduced^??and EMPA-REG OUTCOME^??are?registered trademarks of?Boehringer Ingelheim. P-LLY MPR-US-101872 CONTACTS: Jennifer Forsyth Director, Public Relations Boehringer Ingelheim Pharmaceuticals, Inc. Email:?jennifer.forsyth@boehringer-ingelheim.com Phone: (203) 791-5889 Stephan Thalen Global Business Communications Eli Lilly and Company Email:?stephan.thalen@lilly.com Phone: (317) 276-8304  

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