Genentech?s Anti-Amyloid Beta Antibody Gantenerumab Granted FDA Breakthrough Therapy Designation in Alzheimer?s Disease

- Open RoAD, a rollover open-label study for the former SCarlet RoAD and Marguerite RoAD OLEs to continue to evaluate the safety and tolerability of long-term administration of gantenerumab in participants with AD.
- GRADUATION, an open-label study to evaluate the pharmacodynamic (PD) effects of once weekly administration of gantenerumab in participants with early AD. The study design is similar to the GRADUATE studies and includes the option of home administration by a caregiver.
- An exploratory OLE of DIAN-TU-001, aiming to build on learnings from DIAN-TU-001 and further investigate the relationship of biomarker changes with cognitive and clinical findings in participants with autosomal dominant AD (ADAD).
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