Shots:
- The US FDA has approved Calquence + bendamustine & rituximab for untreated MCL in patients not for autologous HSCT, also transforming its accelerated approval (Oct 2017) to full approval for previously treated MCL. The combination is under review in Australia, Canada, Switzerland, the EU, Japan & other regions
- Approval was based on P-III (ECHO) study of the combination vs chemoimmunotherapy alone (SoC) in previously untreated MCL adults (over 65yrs.; n=635)
- Trial depicted PFS of 27%, with mPFS of 66.4 vs 49.6mos. & improved PFS of 36% after censoring COVID-19 deaths; OS was immature but a favorable trend was observed, despite 69% of chemoimmunotherapy patients receiving BTK inhibitors upon relapse
Ref: AstraZeneca | Image: AstraZeneca
Related News:- Daiichi Sankyo and AstraZeneca Receives the US FDA Approval for Datroway (Datopotamab Deruxtecan-dlnk) to Treat HR+/HER2- Metastatic Breast Cancer
PharmaShots! Your go-to media platform for customized news ranging for multiple indications. For more information connect with us at connect@pharmashots.com
