AstraZeneca Presents (XALOC) Programme Results of Fasenra (benralizumab) for the Treatment of Severe Eosinophilic Asthma at ERS 2022
- The (XALOC) RWE program consists of (XALOC-1 & 2) study evaluating Fasenra in 750+ & 400+ patients along with the (ImPROve Asthma) study in Germany with SEA
- The (XALOC-1) study results showed an AAER reduction of 84% @48wk. over baseline in an overall patient population, reduction in AAER of 79–91% across patient subgroups regardless of atopic status, CRSwNP comorbidity, maintenance OCS use, FeNO & blood eosinophil cut-offs, improvements in asthma control
- The (ImPROve Asthma) study, part of the (XALOC-2) study showed improvements across PROs measures in the total SEA cohort & CRSwNP, 35% achieved clinical remission @6mos. in a real-world setting & 44% with SEA & comorbid CRSwNP, and no decrease of forced expiratory volume in FEV1 ≥200 mL vs baseline
Ref: Pharmiweb | Image: AstraZeneca
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