Shots:

• The P-III ASCEND program includes 5 studies i.e ASCEND-ND, D, ID, NHQ & TD studies evaluating efficacy & safety of daprodustat vs ESA in ~8,000 patients with anemia due to CKD for ~ 4.26yrs.
• The ASCEND-ND & D studies met its 1EPs i.e., the therapy was improved or maintained Hg within the target range. The prespecified primary safety analysis of the ITT population showed similar rates of MACE & achieved non-inferiority without increased CV risk compared to ESA
• Additionally, the results also showed an improvement in Hb levels in non-dialysis patients & QoL in the ASCEND-NHQ trial compared to PBO & maintain Hb levels in high-risk incident dialysis population in the ASCEND-ID trial

 Ref: GSK | Image: GSK