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Agios Publishes P-III (ACTIVATE-T) Study Results of Pyrukynd (mitapivat) for Pyruvate Kinase Deficiency in The Lancet Haematology

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Agios Publishes P-III (ACTIVATE-T) Study Results of Pyrukynd (mitapivat) for Pyruvate Kinase Deficiency in The Lancet Haematology

Shots:

  • The P-III (ACTIVATE-T) study evaluate mitapivat in 27 adults patients with PK deficiency who are regularly transfused
  • The study met its 1EPs i.e., 37% of patients achieved a ≥33% reduction in transfusion burden @24wk. fixed dose period; 9 achieved a ≥50% reduction, 22% reached a transfusion-free status & 11% achieved Hb concentrations in the normal range @≥8wks. after a transfusion, improvements in 2 PK deficiency–specific PROs measures. The safety profile was consistent with prior reported data, grade ≥3 (30%) with no serious AEs & 1 patient experienced dose reduction due to AEs
  • Pyrukynd was approved in the US for hemolytic anemia in adults with PK deficiency & is also under EMA’s review with an expected regulatory decision in the EU at the end of 2022

Ref: Globenewswire | Image: Agios

Click here to­ read the full press release 

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Neha is a Senior Editor at PharmaShots. She is passionate and very enthusiastic about recent updates and developments in the life sciences and pharma industry. She covers Biopharma, MedTech, and Digital health segments along with different reports at PharmaShots. She can be contacted at connect@pharmashots.com.

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