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Ionis Reports 35 Week Interim Analysis of Eplontersen in P-III (NEURO-TTRansform) Study for Hereditary Transthyretin-Mediated Amyloid Polyneuropathy

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Ionis Reports 35 Week Interim Analysis of Eplontersen in P-III (NEURO-TTRansform) Study for Hereditary Transthyretin-Mediated Amyloid Polyneuropathy

Ionis Reports 35 Week Interim Analysis of Eplontersen in P-III (NEURO-TTRansform) Study for Hereditary Transthyretin-Mediated Amyloid Polyneuropathy

Shots: 

  •  The P-III (NEURO-TTRansform) study evaluates the efficacy & safety of eplontersen vs PBO in patients with hereditary   transthyretin-mediated amyloid polyneuropathy (ATTRv-PN) 
  •  The results showed a significant & clinical change from baseline for the co-1EPs of percent change in serum TTR     concentration & mNIS+7. The therapy also met its 2EPs of change from baseline in Norfolk QoL-DN which showed an       improvement in patient-reported QoL 
  •  The therapy has a favorable safety & tolerability profile with no specific concerns & the results were consistent with the     clinical profile across other LICA programs. Ionis & AstraZeneca are expected to file an NDA with the US FDA in 2022 & will seek regulatory approval for eplontersen in ATTRv-PN

Ref: PRNewswire | Image: Ionis

Click here to­ read the full press release 

Neha

Neha is a Senior Editor at PharmaShots. She is passionate and very enthusiastic about recent updates and developments in the life sciences and pharma industry. She covers Biopharma, MedTech, and Digital health segments along with different reports at PharmaShots. She can be contacted at connect@pharmashots.com.

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