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Protagonist Reports Results of PN-943 in P-II (IDEAL) Study for the Treatment of Ulcerative Colitis

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Protagonist Reports Results of PN-943 in P-II (IDEAL) Study for the Treatment of Ulcerative Colitis

Shots:

  • The P-II (IDEAL) study evaluating PN-943 (450/150mg, BID) vs PBO in 159 patients with UC for 12wks. The trial failed to meet the prespecified 1EPs, patients treated with a 150mg dose achieved 27.5% clinical remission with a delta of 13% over PBO in the mITT group & delta of 16% in the bio-naïve
  • The therapy showed strong concordance across multiple parameters including histological remission & endoscopic improvement, safety analyses were similar b/w both groups, patients achieved clinical PoC & validation for PN-943
  • The therapy showed a clear & consistent treatment effect across key EPs & dose-response was consistent with multiple other modalities. The company plans to initiate a P-III study of PN-943

Ref: Protagonist | Image: Protagonist

Click here to­ read the full press release 

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Neha is a Senior Editor at PharmaShots. She is passionate and very enthusiastic about recent updates and developments in the life sciences and pharma industry. She covers Biopharma, MedTech, and Digital health segments along with different reports at PharmaShots. She can be contacted at connect@pharmashots.com.

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