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Otonomy Reports Results of OTO-413 in P-IIa Clinical Trial for the Treatment of Hearing Loss

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Otonomy Reports Results of OTO-413 in P-IIa Clinical Trial for the Treatment of Hearing Loss

Otonomy Reports Results of OTO-413 in P-IIa Clinical Trial for the Treatment of Hearing Loss

Shots:

  • The P-IIa trial evaluates OTO-413 (0.3mg) as single intratympanic vs PBO in 33 patients with hearing loss
  • The results from the 30 patients included 20 with OTO-413 & 10 with PBO showed 40% improvement on 1 of 3 SIN tests (40% vs 20%); improvement by 2 different SIN tests (15% vs 0%) @Day 57 & 85; words-in-noise test (40% vs 0%); responder rate was favorable with an improvement in 1 SIN test (41% vs 13%)
  • PGIC showed a treatment benefit (50% vs 10%), was well tolerated with no SAEs & no patient discontinued, patients reported AE (32% vs 46%). The company plans to initiate a full dose-ranging P-II trial at the end of 2022 & enrollment in higher dose cohorts is ongoing with expected results in H2’22

Ref: Globe Newswire | Image: Otonomy

Click here to­ read the full press release 

Neha

Neha is a Senior Editor at PharmaShots. She is passionate and very enthusiastic about recent updates and developments in the life sciences and pharma industry. She covers Biopharma, MedTech, and Digital health segments along with different reports at PharmaShots. She can be contacted at connect@pharmashots.com.

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