Blueprint Presents Proof-of-Concept Data of BLU-945 in P-I/II (SYMPHONY) Trial for EGFR-Mutant Non-Small Cell Lung Cancer at AACR 2022
Shots:
- The P-I/II (SYMPHONY) trial evaluates BLU-945 in patients with EGFR-mutant NSCLC. The results showed early evidence of safety & clinical activity consistent with preclinical data
- The P-I (SYMPHONY) trial showed dose-dependent reductions in ctDNA & radiographic tumor including PR & PK results showed BLU-945 exposures at higher doses associated with broad EGFR mutation coverage, were well-tolerated with no significant AEs
- The company initiates (SYMPHONY) trial of BLU-945 + osimertinib in patients with 2L or later EGFR-mutant NSCLC. Under the clinical trial supply agreement with AstraZeneca, Blueprint will evaluate BLU-945 & BLU-701 in combination with osimertinib in (SYMPHONY) & (HARMONY) trials
Ref: Blueprint Medicine | Image: Linkedin
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