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Innovent Presents Results of IBI306 in P-III (CREDIT-2) Study for the Treatment of Heterozygous Familial Hypercholesterolemia at ACC 2022

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Innovent Presents Results of IBI306 in P-III (CREDIT-2) Study for the Treatment of Heterozygous Familial Hypercholesterolemia at ACC 2022

Innovent Presents Results of IBI306 in P-III (CREDIT-2) Study for the Treatment of Heterozygous Familial Hypercholesterolemia at ACC 2022

Shots:

  • The P-III (CREDIT-2) study evaluates IBI306 (150mg, q2w, 450mg, q4w) vs PBO in a ratio (2:1:2:1) in 148 patients with HeFH
  • The results showed that patients with both IBI306 (150mg, q2w, 450mg, q4w) achieved a reduction in LDL-C levels. The 2EPs showed ≥50% LDL-C reductions @12wks. (58.5% for 150mg, q2w) & (73.4 for 450mg, q4w), reduced Lp (a) levels (-43.3% & −34.1%), multiple improvements including LDL-C < 1.8 mmol/L response rate, non-HDL-C, ApoB & other Lipid parameters after 12wks.
  • LDL-C reduction was well maintained at ≥50% @24wks. & the safety profile was similar to other marketed PCSK-9 inhibitors. The company plans to submit an NDA in 2022 & will meet with regulatory authorities to benefit the Chinese patients

Ref: PR Newswire | Image: Innovent

Click here to­ read the full press release 

Neha

Neha is a Senior Editor at PharmaShots. She is passionate and very enthusiastic about recent updates and developments in the life sciences and pharma industry. She covers Biopharma, MedTech, and Digital health segments along with different reports at PharmaShots. She can be contacted at connect@pharmashots.com.

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