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Eli Lilly Reports Results of Mirikizumab in P-III (LUCENT-1) Induction Study for the Treatment of Ulcerative Colitis

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Eli Lilly Reports Results of Mirikizumab in P-III (LUCENT-1) Induction Study for the Treatment of Ulcerative Colitis

Shots:

  • The P-III LUCENT-1 induction study evaluates mirikizumab vs PBO in 1162 patients with UC who had failed conventional & biologic treatments for 12wks.
  • The results showed that patients achieved the 1EPs of clinical remission (24.2% vs 13.3%), improved symptom relief & resolution, clinical response (63.5% vs 42.2%, symptomatic remission (45.5% vs 27.9%), improvement in symptoms @4wks., reduction in bowel urgency @2wks. & sustained through 12wks.
  • The safety profile was similar to previous studies in UC & consistent with other anti-IL-23p19 Abs. The company plans to submit a BLA to the US FDA for approval of mirikizumab in UC, followed by submissions to other regulatory agencies in H1’22

 Ref: Lilly | Image: Eli Lilly

Click here to­ read the full press release 

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