BMS Presents Results of Opdivo (nivolumab) + CT or Yervoy (ipilimumab) in P-III CheckMate -648 Trial for Unresectable Advanced or Metastatic ESCC at ASCO 2021
Shots:
- The P-III CheckMate -648 trial evaluating Opdivo + CT or Opdivo (3 mg/kg- q2w) + Yervoy (1 mg/kg- q6w up to 24mos.) in patients with unresectable advanced or metastatic ESCC
- Results: Both combinations showed OS benefits over CT in PD-L1 positive & all-randomized populations- m-OS for Opdivo + CT (13.7 vs 9.1 mos. & 13.2 vs 10.7 mos.) & for Opdivo + CT (3.7 vs 9.1 mos. & 2.8 vs 10.7 mos.); mDoR (8.4 vs 11.8 mos.) & 5.7 mos. for CT alone; ORR (53% vs 35%) & 20% for CT alone
- Additionally- Opdivo + CT showed improvement in PFS with an m-PFS (6.9 vs 4.4 mos.) while Opdivo + Yervoy failed to meet its 1EPs of PFS- safety profiles were consistent with previously reported for other tumors
Ref: Businesswire | Image: BMS
Click here to read the full press release
This content piece was prepared by our former Senior Editor. She had expertise in life science research and was an avid reader. For any query reach out to us at connect@pharmashots.com