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ONO and BMS' Opdivo + Yervoy Receive Approval for 1L Treatment for Unresectable Advanced or Recurrent Malignant Pleural Mesothelioma

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ONO and BMS' Opdivo + Yervoy Receive Approval for 1L Treatment for Unresectable Advanced or Recurrent Malignant Pleural Mesothelioma

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  • The approval is based on P-III CheckMate -743 study assessing Opdivo + Yervoy vs SOC Pt. based CT in patients with previously untreated unresectable malignant pleural mesothelioma
  • The combination regimen has demonstrated significant extension of OS vs CT. The safety profile of combination treatment was consistent with those previously reported in the studies for the combination treatment
  • Opdivo is a PD-1 immune checkpoint inhibitor- designed to harness the body’s immune system to help restore anti-tumor immune response. Yervoy is a recombinant- mAb and binds to the CTLA-4

  Ref: Ono Pharma | Image: BMS

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