Shots:

• The AURORA 2 involves assessing Lupkynis vs control arm in 216 patients who have completed P-III AURORA 1 study for 1 year
• Results: reduction in UPCR from pre-treatment baseline to year 2 (-3.1 vs -2.1 mg/mg); reduction proteinuria b/w 1 & 2year (1.0 vs 0.6 mg/mg); stable renal function. In general- the interim analysis of AURORA 2 showed that the patients treated with Lupkynis for up to 2yrs. sustained reductions in proteinuria- with no change in mean eGFR @104wks.
• Additionally- the EULAR presentation will highlight RWE suggesting reduced economic burden to healthcare payers when achieving lower LN disease activity

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