Shots:

• The parties will initially develop up to 6 in vivo gene therapy programs utilizing Poseida's piggyBac- Cas-CLOVER & biodegradable nanoparticle technology for 6 liver & HSC directed indications. Takeda has an option to add 2 additional programs and is obligated to provide funding for all program's R&D costs
• Poseida to receive $45M up front & preclinical milestones exceeding $125M- if milestones for 6 programs are achieved. The company is also eligible for ~2.7B milestones for all 6 programs and ~$3.6B if the milestones related to the 2 optional programs are also achieved
• Poseida will lead research activities up to candidate selection- after which Takeda will lead development & commercialization

  | Ref: PR Newswire | Image: Poseida