Boehringer Ingelheim Enters into a Clinical Collaboration with Amgen to Evaluate BI 1701963 + Lumakras (sotorasib) for Locally Advanced or Metastatic NSCLC
Shots:
- The companies collaborated to evaluate the synergistic effects of BI 1701963 (SOS1::pan-KRAS inhibitor) + Lumakras (KRAS G12C inhibitor) in a P-I trial for adult patients with LA or metastatic NSCLC
- The companies will jointly share costs & manage the clinical development for combined therapy. Amgen will sponsor the trial
- The preclinical data showed that the combination may result in increased anti-tumor activity based on complementary mechanisms of targeted oncology agents. BI 1701963 is currently being evaluated in P-I trials as monothx. and in combination with MEK inhibitors- KRASG12C inhibitors- or irinotecan for the treatment of advanced KRAS-mutated cancers
| Ref: Boehringer Ingelheim | Image: Longevity Technology
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