Shots:

• The P-lll RUXCOVID study involves assessing Ruxolitinib (5mg- bid) + SoC therapy vs PBO + SoC therapy in 432 patients aged ≥12 yrs. in a ratio (2:1) hospitalized for COVID-19 and not intubated or receiving ICU care prior to randomization
• The study did not meet its 1EPS of reducing the number of hospitalized COVID-19 patients who experienced severe complications @29days (death- mechanical ventilation or ICU care i.e. (12% vs 11.8%). The trial did not show benefits among 2EPs and exploratory endpoints including mortality rate @Day29 and time to recovery
• Ruxolitinib is an oral JAK 1 and JAK 2 tyrosine kinases inhibitor and is approved under the name Jakavi in EU and other countries for PV & MF

 ­ Ref: Novartis | Image: Novartis