Shots:
- Arrowhead has reported P-I/IIa (ARO-DIMER-PA-1001) study data assessing the safety, tolerability, PK, PD, & effects on LDL-C and TGs of single-dose (part 1) & multiple doses (part 2) of ARO-DIMER-PA in ~78 adults with mixed hyperlipidemia
- ARO-DIMER-PA single doses produced dose-dependent mean maximal reductions in serum PCSK9 of 72% & APOC3 of 88%, along with mean maximal reductions in LDL-C (54%), TGs (73%), non-HDL cholesterol (61%) & ApoB (50%)
- ARO-DIMER-PA is a dual-functional RNAi molecule designed to silence both PCSK9 & APOC3 genes in hepatocytes
Ref: Businesswire | Image: Arrowhead | Press Release
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