Shots:

• The P-lll GALACTIC-HF study involves the assessing of Omecamtiv mecarbil (25mg- bid with the maintenance dose of 50 mg- 37.5mg- or 25mg- bid) vs PBO in 8-256 patients with HFrEF
• Result: The study met its 1EPs of reduction in CV death or HF events (HF hospitalization and other urgent treatment for HF) while the study did not meet its 2EPs of reduction in time to CV death- presented at AHA 2020
• Omecamtiv mecarbil is a cardiac myosin activator- targeting the contractile mechanisms of the heart- being developed under a collaboration between Amgen and Cytokinetics- with funding and strategic support from Servier
  
   ­ Ref: Amgen | Image: The Times