Shots:

• The P-IIb/III SELECTION study involves assessing of filgotinib (200/ 100mg) vs PBO in 1-348 biologic-naïve & biologic-experienced patients in a ratio (2:2:1) with mod. to sev. UC. The SELECTION study consists of 2 induction trials and a maintenance trial
• Filgotinib (200mg) achieved all its 1EPs inducing clinical remission @10wks. in biologic-naïve & experienced patients (26.1 % vs 15.3% & 11.5% vs 4.2%) and maintaining clinical remission @58wks. (37.2% vs 11.2) while in 100mg arm- clinical remission @58wks. (23.8% vs 13.5%) and did not achieve clinical remission @10wks.
• Filgotinib is an investigational- oral- selective JAK1 inhibitor and is currently under US FDA- EMA and MHLW’s review the for the treatment of RA

­ Ref: Gilead | Image: Galapagos 

Related News: Gilead Reports Submission of Filgotinib’s NDA Under Priority Review to the US FDA for Rheumatoid Arthritis Treatment