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Bicycle Reports First Patient Dosing in P-IIa Study of BT1718 for MT1-MMP-Positive Squamous NSCLC

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Bicycle Reports First Patient Dosing in P-IIa Study of BT1718 for MT1-MMP-Positive Squamous NSCLC

Shots:

  • The first patient has been dosed in the P-IIa expansion portion of P- I/IIa study- assessing BT1718 (qw) at RP2D of 20 mg/m2  in patients with MT1-MMP+ sq. NSCLC and a basket of other MT1-MMP+ solid tumors
  • The focus of the study is to evaluate the safety and tolerability profiles of BT1718 while the secondary objective is to assess the anti-tumor response. The study is sponsored by Cancer Research UK
  • BT1718 is a BTC targeting MT1-MMP and is consist of a mono-hindered disulfide cleavable linker and a cytotoxic DM1 payload

­ Ref: Businesswire | Image: Businesswire

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