Astellas and Seattle Genetics’ PADCEV (enfortumab vedotin-ejfv) Receives the US FDA’s Approval for Locally Advanced or Metastatic Urothelial Cancer in Adults

 Astellas and Seattle Genetics’ PADCEV (enfortumab vedotin-ejfv) Receives the US FDA’s Approval for Locally Advanced or Metastatic Urothelial Cancer in Adults

Astellas Signs an Exclusive License Agreement with Pandion to Deliver Immunomodulators for Autoimmune Diseases of the Pancreas

  • The PADCEV was evaluated in P-II EV-201 Trial to evaluate 125 patients locally advanced or metastatic urothelial cancer who received who received prior treatment with a PD-1 or PD-L1 inhibitor and a Pt-based CT
  • The study resulted in ORR 44%, CR 12% leading no cancer detection at time of assessment, PR 32% meaning a decrease in tumor size or extent of cancer in the body, DoR 7.6 mos.
  • PADCEV is a novel ADC directed against Nectin-4 a protein located on the surface of cells and highly expressed in bladder cancer and is currently evaluated in P-III EV-301Trial

Click here to read full press release/ article | Ref: Astellas | Image: Behance

Shiwani Sharma

Shiwani Sharma was Senior Editor at PharmaShots. She has in-depth knowledge of the life sciences industry including the Pharma and Biotech sectors. Any articles written by her can be contacted at connect@pharmashots.com.

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