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GSK Reports Results of M72/AS01E in P-IIb Study for the Prevention of Pulmonary Tuberculosis Disease

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GSK Reports Results of M72/AS01E in P-IIb Study for the Prevention of Pulmonary Tuberculosis Disease

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  • The P-IIb study involves assessing of M72/AS01E vs PBO in 3-573 adults in a ratio (1:1) to prevent Mycobacterium tuberculosis infection from developing pulmonary tuberculosis disease in tuberculosis-endemic regions across 11 sites in Kenya- South Africa and Zambia
  • The P-IIb study results demonstrated a reduction in the incidence of pulmonary TB in HIV-negative adults with latent TB infection with an overall efficacy of 50% for three yrs. following vaccination- acceptable safety- and reactogenicity
  • M72/AS01E contains the M72 recombinant fusion protein- derived from two Mycobacterium tuberculosis antigens (Mtb32A and Mtb39A) combining with its Adjuvant System AS01- providing protection against TB

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Ref: GSK | Image: GSK


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