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GSK Reports the P-III (GLISTEN) Study Results of Linerixibat for Primary Biliary Cholangitis (PBC) Patients with Cholestatic Pruritus

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  • GSK has reported P-III (GLISTEN) trial data assessing linerixibat (n=119) vs PBO (n=119) to treat PBC pts (N=238) with cholestatic pruritus; pts could switch to linerixibat in Part B of the trial
  • Trial met its 1EP, showing significantly reduced itch per WI-NRS scale in PBC pts, as assessed by monthly itch score, over 24wks.
  • Trial also met its key 2EPs, showing rapid & sustained itch relief at Wk. 2 as well as reduced itch-related sleep interference over 24wks., with 56% vs 43% achieving significant itch improvement (WI-NRS ≥3-point reduction) at Wk. 24; data was presented at EASL 2025

Ref: GSK | Image: GSK

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