GSK to Acquire IDRx for ~1.15B, Boosting its GI Cancer Portfolio

Shots:

• GSK to acquire IDRx incl. its lead candidate IDRX-42, for $1B upfront & ~$150M in regulatory milestones (total ~$1.15B). It will also pay success-based milestones & tiered royalties to Merck KGaA for IDRX-42
• IDRX-42 (TKI, small molecule) targets key KIT mutations, responsible for proliferation & survival of tumor cells, & is under P-I/Ib (StrateGIST 1) trial for 1L & 2L treatment of greater GIST & KIT mutated patients. GSK will expedite the development this year
• The study showed ORR of 29% (n=87, incl. 1 CR & 24 PRs) in efficacy-evaluable 2L patients & 53% (n=15, incl. 1 CR & 7PRs) in those who received 1L therapy; 2 PRs were awaiting verification at the cut off. Safety was favorable, with data highlighted at CTOS 2024

Ref: GSK | Image: IDRx

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