Shots:

• The P-III CASPIAN study involves assessing of Imfinzi + etoposide + cisplatin/carboplatin or Imfinzi + tremelimumab + CT vs CT as monothx. as a 1L treatment for patients with extensive-stage SCLC across 22 countries including the US & EU
• The P-III CASPIAN study resulted in meeting its 1EPs i.e- improvement in overall survival in SCLC patients. The safety & tolerability of combination therapy is consistent with the known safety profile
• Imfinzi is a mAb targeting PD-L1- act by blocking the interaction of PD-L1 with PD-1 and CD80 and is an approved therapy in 45+ countries including the US- EU & Japan based on P-III PACIFIC study for unresectable- Stage III NSCLC

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